<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001997116</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001041024</issuerCik>
      <issuerName>ROCKWELL MEDICAL, INC.</issuerName>
      <secFileNumber>000-23661</secFileNumber>
      <issuerAddress>
        <com:street1>30142 WIXOM ROAD</com:street1>
        <com:city>WIXOM</com:city>
        <com:stateOrCountry>MI</com:stateOrCountry>
        <com:zipCode>48393</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8004493353</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Neri Jesse</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Raymond James &amp; Associates</name>
        <address>
          <com:street1>880 Carillon Parkway</com:street1>
          <com:city>St. Petersburg</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33716</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>886</noOfUnitsSold>
      <aggregateMarketValue>939.00</aggregateMarketValue>
      <noOfUnitsOutstanding>34056920</noOfUnitsOutstanding>
      <approxSaleDate>04/01/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/14/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8666</amountOfSecuritiesAcquired>
      <paymentDate>04/14/2025</paymentDate>
      <natureOfPayment>RSU Vesting</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/01/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/13/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Maressia Rooks-Bailey, as duly authorized representative of Raymond James &amp; Associates, Inc., as attorney-in-fact for Jesse T Neri</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
