Stock-Based Compensation - Service Based Stock Options (Details) - Stock option awards - service based awards - USD ($)	9 Months Ended		12 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Dec. 31, 2020
Shares Underlying Options
Outstanding at the beginning of the period (in shares)	528,591	519,814	519,814
Granted (in shares)	898,659	170,197
Forfeited (in shares)	(30,093)	(35,025)
Expired (in shares)	(85,466)	(121,202)
Outstanding at the end of the period (in shares)	1,311,691	533,784	528,591	519,814
Exercisable at end of period (in shares)	243,973	230,858
Weighted Average Exercise Price
Outstanding at the beginning of the period (in dollars per share)	$ 32.01	$ 50.05	$ 50.05
Granted (in dollars per share)	1.49	9.79
Forfeited (in dollars per share)	15.11	25.30
Expired (in dollar per share)	82.09	78.76
Outstanding at the end of the period (in dollars per share)	8.23	32.45	$ 32.01	$ 50.05
Exercisable at end of the period (in dollars per share)	$ 29.31	$ 54.56
Weighted Average Remaining Contractual Term
Outstanding	9 years 1 month 6 days	7 years 8 months 12 days	7 years 6 months	6 years 7 months 6 days
Granted	5 years 6 months	6 years
Exercisable at end of the period	6 years 10 months 24 days	5 years 9 months 18 days
Aggregate Intrinsic Value
Outstanding	$ 0	$ 0	$ 0	$ 0
Exercisable at end of the period	$ 0	$ 0