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Going Concern (Details) - USD ($)
1 Months Ended 9 Months Ended
Jul. 09, 2019
Jun. 20, 2019
Jun. 17, 2019
Mar. 22, 2019
Apr. 30, 2019
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Cash and cash equivalents           $ 14,421,394   $ 22,713,980
Investments available-for -sale           14,575,589   10,818,059
Working capital           28,200,000    
Accumulated deficit           (299,213,836)   $ (272,388,234)
Net cash used in operating activities           $ (21,953,959) $ (14,635,691)  
Proceeds from the issuance of common stock         $ 2,296,235      
Common stock, no par value ( in dollars per share)           $ 0.0001   $ 0.0001
Remaining common stock value available for issuance           $ 37,700,000    
Maximum                
Sales agreement       $ 40,000,000        
Public offering                
Number of shares issued   5,833,334            
Price per share   $ 3.00            
Proceeds from the issuance of common stock   $ 16,100,000       $ 18,777,642    
Over allotment                
Number of shares issued 425,800              
Price per share $ 3.00              
Proceeds from the issuance of common stock $ 1,200,000              
Sales agreement     $ 875,000