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Distribution Agreement (Details) - Baxter Healthcare Organization - USD ($)
12 Months Ended
Oct. 02, 2014
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Distribution agreement term 10 years      
Upfront fee $ 20,000,000      
Recognized Distribution Agreement Income   $ 2,099,028 $ 2,065,785 $ 2,081,668
Payment (made) received   $ 0    
Agreement termination notice period   270 days    
Agreement termination significant price increase notice period   45 days    
Agreement termination limited non-compete period   2 years    
Agreement Refund Trigger Event repayment percent first criteria   33.00%    
Agreement Refund Trigger Event repayment percent second criteria   25.00%    
Agreement property infringement repayment amount first criteria   $ 10,000,000    
Agreement property infringement repayment amount second criteria   $ 6,600,000    
Agreement extension period   5 years    
Extension fee   $ 7,500,000