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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash Flows From Operating Activities:      
Net (Loss) $ (19,802,916) $ (14,420,450) $ (21,327,157)
Adjustments To Reconcile Net Loss To Net Cash Used In Operating Activities:      
Depreciation and Amortization 762,368 822,294 996,321
Share Based Compensation- Employees 10,346,284 8,887,977 10,094,685
Restricted Stock Retained in Satisfaction of Tax Liabilities   (2,912,859)  
Loss on Disposal of Assets 8,168 5,281 7,338
(Gain) on Sale of Investments Available for Sale 26,820 58,095 1,223
Amortization of Debt Issuance Costs     882,716
Non-cash Interest Expense     874,942
Changes in Assets and Liabilities:      
(Increase) Decrease in Accounts Receivable (1,162,469) (574,731) 106,317
(Increase) in Inventory (6,095,846) (3,951,595) (1,120,537)
(Increase) in Other Assets (1,230,084) (360,303) (13,466)
Increase (Decrease) in Accounts Payable 1,863,018 (1,299,299) (3,391,638)
Increase (Decrease) in Other Liabilities 191,134 (413,652) (2,345,486)
Increase (decrease) Deferred License Revenue (2,065,785) (2,081,668) 19,492,520
Increase (decrease) in Deferred International Partnership Revenue 4,706,670    
Changes in Assets and Liabilities (3,793,362) (8,681,248) 12,727,710
Cash (Used In) Operating Activities (12,452,638) (16,240,910) 4,257,778
Cash Flows From Investing Activities:      
Purchase of Investments Available for Sale (25,781,853) (21,800,000) (13,100,000)
Sale of Investments Available for Sale 24,491,677 1,468,656 4,976,000
Purchase of Equipment (355,264) (815,002) (684,593)
Proceeds from Sale of Assets 1,000 4,800  
Cash Provided by (Used In) Investing Activities (1,644,440) (21,141,546) (8,808,593)
Cash Flows From Financing Activities:      
Proceeds from the Issuance of Common Shares and Purchase Warrants 80,161 2,780,187 79,569,815
Payments on Notes Payable and Capital Lease Obligations     (21,100,000)
Cash Provided By Financing Activities 80,161 2,780,187 58,469,815
Effects of exchange rate changes (671)    
(Decrease) Increase In Cash (14,017,588) (34,602,269) 53,919,000
Cash At Beginning Of Period 31,198,182 65,800,451 11,881,451
Cash At End Of Period 17,180,594 $ 31,198,182 65,800,451
Supplemental Cash Flow Information:      
Interest Paid     $ 3,518,168
Income Taxes Paid $ 404,527