November 29, 2018

Stuart Paul
Chief Executive Officer
Rockwell Medical, Inc.
30142 Wixom Road
Wixom, Michigan 48393

       Re: Rockwell Medical, Inc.
           Registration Statement on Form S-3
           Filed November 16, 2018
           File No. 333-228437

Dear Mr. Paul:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Michael Fay at 202-551-3812 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Electronics and Machinery
cc:    Mr. Ryan A. Murr