NPORT-P false 0001039803 XXXXXXXX S000003965 C000011092 ProFunds 811-08239 0001039803 549300HM4OOUYSE5DP77 7272 Wisconsin Avenue 21st Floor Bethesda 20814 240-497-6400 PROFUND VP BIOTECHNOLOGY S000003965 G74DJGSGIKRN0SEEG418 2025-12-31 2025-06-30 N 31021146.98 1957444.54 29063702.44 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 73694.67 N Dow Jones U.S. Biotechnology Index DJUSBT ImmunityBio Inc 529900J9XLBR4HFL4B83 45256X103 18412.00000000 NS USD 48607.68000000 0.167245312603 Long EC CORP US N 1 N N AGPXX N/A 825252885 1153194.50000000 NS USD 1153194.50000000 3.967816909702 Long STIV RF US N 1 N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 03753U106 10491.00000000 NS USD 181599.21000000 0.624831644815 Long EC CORP US N 1 N N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 45826J105 9392.00000000 NS USD 88096.96000000 0.303116783492 Long EC CORP US N 1 N N N ORIC Pharmaceuticals Inc. 54930033FJRNEYBW0L25 68622P109 3110.00000000 NS USD 31566.50000000 0.108611420259 Long EC CORP US N 1 N N N AbbVie Inc. FR5LCKFTG8054YNNRU85 00287Y109 3661.00000000 NS USD 679554.82000000 2.338156404549 Long EC CORP US N 1 N N N Iovance Biotherapeutics Inc 2549002L8WT2ACU5Q878 462260100 21328.00000000 NS USD 36684.16000000 0.126219844411 Long EC CORP US N 1 N N N Scholar Rock Holding Corp. 549300Z1FLPGL4OWJ459 80706P103 7282.00000000 NS USD 257928.44000000 0.887458989550 Long EC CORP US N 1 N N N N/A N/A N/A 67000.00000000 PA USD 67000.00000000 0.230528096474 Long RA CORP US N 2 Repurchase Y 4.26000000 2025-07-01 127800.00000000 USD 68353.11000000 USD UST N N N Natera Inc. N/A 632307104 4204.00000000 NS USD 710223.76000000 2.443679574088 Long EC CORP US N 1 N N N N/A N/A N/A 27000.00000000 PA USD 27000.00000000 0.092899382161 Long RA CORP US N 2 Repurchase Y 4.24000000 2025-07-01 27200.00000000 USD 27637.57000000 USD UST N N N Rigel Pharmaceuticals Inc. 529900KPTNUS5J8K9K66 766559702 1335.00000000 NS USD 25004.55000000 0.086033601712 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc. 529900S3ZI14OWRJII50 02043Q107 2348.00000000 NS USD 765659.32000000 2.634417695338 Long EC CORP US N 1 N N N Arbutus Biopharma Corp. 25490064CESONAUIAS23 03879J100 6451.00000000 NS USD 19933.59000000 0.068585859083 Long EC CORP CA N 1 N N N Stoke Therapeutics Inc 549300RD25SS2DIJHJ67 86150R107 3753.00000000 NS USD 42596.55000000 0.146562710266 Long EC CORP US N 1 N N N Celldex Therapeutics Inc. 529900F018DMYWH38923 15117B202 5219.00000000 NS USD 106206.65000000 0.365427117275 Long EC CORP US N 1 N N N Metsera Inc. N/A 59267L107 1407.00000000 NS USD 40029.15000000 0.137729011238 Long EC CORP US N 1 N N 89bio Inc. N/A 282559103 8923.00000000 NS USD 87623.86000000 0.301488979874 Long EC CORP US N 1 N N N Geron Corp. 549300T282D7Z2YESL90 374163103 60421.00000000 NS USD 85193.61000000 0.293127175300 Long EC CORP US N 1 N N N Viridian Therapeutics Inc 549300C775BNYF550E70 92790C104 5573.00000000 NS USD 77910.54000000 0.268068186291 Long EC CORP US N 1 N N N Mirum Pharmaceuticals Inc. 254900YZKR40F7F27K81 604749101 2713.00000000 NS USD 138064.57000000 0.475041231532 Long EC CORP US N 1 N N N Novavax Inc 529900J4GJHPEPQ23205 670002401 18524.00000000 NS USD 116701.20000000 0.401535902870 Long EC CORP US N 1 N N N Recursion Pharmaceuticals Inc N/A 75629V104 25974.00000000 NS USD 131428.44000000 0.452208180534 Long EC CORP US N 1 N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 803607100 10797.00000000 NS USD 184628.70000000 0.635255265158 Long EC CORP US N 1 N N N KalVista Pharmaceuticals Inc. 529900Q7IDA3WUGRZA51 483497103 3421.00000000 NS USD 38674.41000000 0.133067733128 Long EC CORP US N 1 N N N Krystal Biotech Inc 549300YONUY68210OE41 501147102 2528.00000000 NS USD 347498.88000000 1.195645601992 Long EC CORP US N 1 N N N Humacyte Inc. N/A 44486Q103 13510.00000000 NS USD 28235.90000000 0.097151765361 Long EC CORP US N 1 N N N Viking Therapeutics Inc. 529900IVC72YPFA25M37 92686J106 11486.00000000 NS USD 304379.00000000 1.047282260848 Long EC CORP US N 1 N N N Spyre Therapeutics Inc 52990017AIJPRH3HQH40 00773J202 3716.00000000 NS USD 55628.52000000 0.191402042168 Long EC CORP US N 1 N N N Xencor Inc 549300V5IF65437JKG30 98401F105 6607.00000000 NS USD 51931.02000000 0.178679987889 Long EC CORP US N 1 N N N Capricor Therapeutics Inc 5493002ZI5PDLXV4DX14 14070B309 3497.00000000 NS USD 34725.21000000 0.119479650163 Long EC CORP US N 1 N N Roivant Sciences Ltd 549300DL466NY5J6U724 G76279101 43091.00000000 NS USD 485635.57000000 1.670934978097 Long EC CORP BM N 1 N N N IDEAYA Biosciences Inc. 549300ULW08F62IJML11 45166A102 8008.00000000 NS USD 168328.16000000 0.579169706087 Long EC CORP US N 1 N N N N/A N/A N/A 32000.00000000 PA USD 32000.00000000 0.110102971450 Long RA CORP US N 2 Repurchase Y 4.10000000 2025-07-01 32000.00000000 USD 32641.63000000 USD UST N N N Syndax Pharmaceuticals Inc. 529900OF94TRHKZVBS87 87164F105 9192.00000000 NS USD 86083.08000000 0.296187590613 Long EC CORP US N 1 N N N Arcus Biosciences Inc. N/A 03969F109 7197.00000000 NS USD 58583.58000000 0.201569569881 Long EC CORP US N 1 N N N ARS Pharmaceuticals Inc N/A 82835W108 5896.00000000 NS USD 102885.20000000 0.353998944946 Long EC CORP US N 1 N N N Emergent Biosolutions Inc 549300YW6TUOX8BE5103 29089Q105 5682.00000000 NS USD 36251.16000000 0.124730013579 Long EC CORP US N 1 N N N Biohaven Ltd N/A G1110E107 8838.00000000 NS USD 124704.18000000 0.429071899072 Long EC CORP VG N 1 N N N Kymera Therapeutics Inc N/A 501575104 2927.00000000 NS USD 127734.28000000 0.439497618253 Long EC CORP US N 1 N N N Verve Therapeutics Inc N/A 92539P101 5487.00000000 NS USD 61619.01000000 0.212013628088 Long EC CORP US N 1 N N N Day One Biopharmaceuticals Inc. N/A 23954D109 7197.00000000 NS USD 46780.50000000 0.160958501748 Long EC CORP US N 1 N N N N/A N/A N/A -135.00000000 OU USD 5802.74000000 0.019965591142 Short DE US N 2 GOLDMAN SACHS GROUP, INC. 784F5XWPLTWKTBV3E584 DOW JONES U.S. BIOTECHNOLOGY INDEX SPSIBI Index This swap is not based on custom baskets or indices Y DOW JONES U.S. BIOTECHNOLOGY INDEX 2025-07-23 0.00000000 USD 0.00000000 USD -872002.80000000 USD 5802.74000000 N N N Arcutis Biotherapeutics Inc. N/A 03969K108 11256.00000000 NS USD 157809.12000000 0.542976657312 Long EC CORP US N 1 N N N Arcellx Inc N/A 03940C100 4111.00000000 NS USD 270709.35000000 0.931434494826 Long EC CORP US N 1 N N N Travere Therapeutics Inc N/A 89422G107 9032.00000000 NS USD 133673.60000000 0.459933142640 Long EC CORP US N 1 N N N Altimmune Inc. 549300EOYCQ8SW3NVE64 02155H200 7439.00000000 NS USD 28788.93000000 0.099054585558 Long EC CORP US N 1 N N Springworks Therapeutics Inc N/A 85205L107 8314.00000000 NS USD 390674.86000000 1.344201967407 Long EC CORP US N 1 N N N Twist Bioscience Corporation 549300T23BL59LCOH584 90184D100 5518.00000000 NS USD 203007.22000000 0.698490567122 Long EC CORP US N 1 N N N Denali Therapeutics Inc 549300ZTQ2HO18L3Q830 24823R105 8916.00000000 NS USD 124734.84000000 0.429177391481 Long EC CORP US N 1 N N N MiMedx Group Inc. N/A 602496101 4593.00000000 NS USD 28063.23000000 0.096557656609 Long EC CORP US N 1 N N N Adma Biologics Inc N/A 000899104 19393.00000000 NS USD 353146.53000000 1.215077572202 Long EC CORP US N 1 N N N Dianthus Therapeutics Inc 549300Z3N6ODPCOFC890 252828108 2080.00000000 NS USD 38750.40000000 0.133329193278 Long EC CORP US N 1 N N N Nurix Therapeutics Inc. N/A 67080M103 5522.00000000 NS USD 62895.58000000 0.216405945284 Long EC CORP US N 1 N N N Cullinan Therapeutics Inc N/A 230031106 2860.00000000 NS USD 21535.80000000 0.074098611642 Long EC CORP US N 1 N N N Nuvalent Inc N/A 670703107 3529.00000000 NS USD 269262.70000000 0.926456980337 Long EC CORP US N 1 N N N VIR Biotechnology Inc N/A 92764N102 9628.00000000 NS USD 48525.12000000 0.166961246937 Long EC CORP US N 1 N N N Cytokinetics Inc 549300BE5DY1HW7IHA64 23282W605 12361.00000000 NS USD 408407.44000000 1.405214772079 Long EC CORP US N 1 N N N Praxis Precision Medicines Inc N/A 74006W207 1809.00000000 NS USD 76068.45000000 0.261730074332 Long EC CORP US N 1 N N N CRISPR Therapeutics AG 506700O6IRRIQLT3W370 H17182108 8339.00000000 NS USD 405608.96000000 1.395585991968 Long EC CORP CH N 1 N N ArriVent BioPharma Inc. N/A 04272N102 1149.00000000 NS USD 25013.73000000 0.086065187501 Long EC CORP US N 1 N N N Taysha Gene Therapies Inc. N/A 877619106 8655.00000000 NS USD 19993.05000000 0.068790444167 Long EC CORP US N 1 N N N N/A N/A N/A 16000.00000000 PA USD 16000.00000000 0.055051485725 Long RA CORP US N 2 Repurchase Y 4.15000000 2025-07-01 16100.00000000 USD 16330.66000000 USD UST N N N Soleno Therapeutics Inc 5493003LCY77N7FXK844 834203309 3457.00000000 NS USD 289627.46000000 0.996526373740 Long EC CORP US N 1 N N N Avidity Biosciences Inc. N/A 05370A108 9253.00000000 NS USD 262785.20000000 0.904169730413 Long EC CORP US N 1 N N N Insmed Inc 529900Q55QAG41CCAC11 457669307 7155.00000000 NS USD 720079.20000000 2.477589362492 Long EC CORP US N 1 N N N Relay Therapeutics Inc N/A 75943R102 13270.00000000 NS USD 45914.20000000 0.157977807868 Long EC CORP US N 1 N N N Verastem Inc 549300IY0EFBIU8NQC81 92337C203 7647.00000000 NS USD 31735.05000000 0.109191353254 Long EC CORP US N 1 N N N Summit Therapeutics Inc. N/A 86627T108 14502.00000000 NS USD 308602.56000000 1.061814339164 Long EC CORP US N 1 N N N/A N/A N/A 99000.00000000 PA USD 99000.00000000 0.340631067925 Long RA CORP US N 2 Repurchase Y 4.30000000 2025-07-01 104500.00000000 USD 100980.20000000 USD UST N N N PTC Therapeutics, Inc. 549300UJLWOIWFDGB318 69366J200 7120.00000000 NS USD 347740.80000000 1.196477980456 Long EC CORP US N 1 N N N Amgen Inc. 62QBXGPJ34PQ72Z12S66 031162100 2402.00000000 NS USD 670662.42000000 2.307560165070 Long EC CORP US N 1 N N N Dyne Therapeutics Inc. N/A 26818M108 8040.00000000 NS USD 76540.80000000 0.263355297412 Long EC CORP US N 1 N N N Dynavax Technologies Corp. 549300T5URIXWDILX594 268158201 11865.00000000 NS USD 117700.80000000 0.404975244441 Long EC CORP US N 1 N N N Alkermes PLC N/A G01767105 11762.00000000 NS USD 336510.82000000 1.157838787727 Long EC CORP IE N 1 N N N Kura Oncology Inc. 5493005QORQTZCZYOP39 50127T109 7665.00000000 NS USD 44227.05000000 0.152172800734 Long EC CORP US N 1 N N N Mineralys Therapeutics Inc. N/A 603170101 4184.00000000 NS USD 56609.52000000 0.194777386387 Long EC CORP US N 1 N N N CG Oncology Inc. N/A 156944100 5851.00000000 NS USD 152126.00000000 0.523422644840 Long EC CORP US N 1 N N N BioCryst Pharmaceuticals Inc. 549300Z0INP1Z5NP6J59 09058V103 21948.00000000 NS USD 196654.08000000 0.676631204871 Long EC CORP US N 1 N N N Biogen Inc W8J5WZB5IY3K0NDQT671 09062X103 5269.00000000 NS USD 661733.71000000 2.276838993125 Long EC CORP US N 1 N N N Ultragenyx Pharmaceuticals Inc 529900EV44GVDN1DCX77 90400D108 5914.00000000 NS USD 215033.04000000 0.739868020751 Long EC CORP US N 1 N N N Crinetics Pharmaceuticals Inc. 549300Q1CNFXK5P31D28 22663K107 6619.00000000 NS USD 190362.44000000 0.654983446768 Long EC CORP US N 1 N N N Exelixis, Inc. 254900PJQB59O2O95R37 30161Q104 16921.00000000 NS USD 745793.08000000 2.566063568602 Long EC CORP US N 1 N N N Revolution Medicines Inc 549300JU3X0LBCQ65892 76155X100 11156.00000000 NS USD 410429.24000000 1.412171215444 Long EC CORP US N 1 N N N Arcturus Therapeutics Holdings Inc N/A 03969T109 2745.00000000 NS USD 35712.45000000 0.122876464461 Long EC CORP US N 1 N N N Blueprint Medicines Corporation 5299004CC60O9T5HVM83 09627Y109 4417.00000000 NS USD 566171.06000000 1.948034876729 Long EC CORP US N 1 N N N Akero Therapeutics Inc 549300SI3KG74LBE2955 00973Y108 6791.00000000 NS USD 362367.76000000 1.246805222934 Long EC CORP US N 1 N N N N/A N/A N/A 33000.00000000 PA USD 33000.00000000 0.113543689308 Long RA CORP US N 2 Repurchase Y 4.26000000 2025-07-01 34000.00000000 USD 34624.54000000 USD UST N N N Catalyst Pharmaceuticals Inc. 5299004O0R5XXLA5H544 14888U101 6980.00000000 NS USD 151466.00000000 0.521151771054 Long EC CORP US N 1 N N N Replimune Group Inc 549300AY704NEIRC4K64 76029N106 5800.00000000 NS USD 53882.00000000 0.185392759615 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals, Inc. 549300RCBFWIRX3HYQ56 75886F107 1352.00000000 NS USD 709800.00000000 2.442221535488 Long EC CORP US N 1 N N N Keros Therapeutics Inc. N/A 492327101 3959.00000000 NS USD 52852.65000000 0.181851056688 Long EC CORP US N 1 N N N GRAIL Inc 2549009XSNESW3VE8024 384747101 2992.00000000 NS USD 153848.64000000 0.529349763051 Long EC CORP US N 1 N N TG Therapeutics Inc 529900X21UKABN9NJ529 88322Q108 13726.00000000 NS USD 493998.74000000 1.699710286464 Long EC CORP US N 1 N N N United Therapeutics Corporation 5299005C4HZL4UWROC14 91307C102 2536.00000000 NS USD 728719.60000000 2.507318541071 Long EC CORP US N 1 N N N Vera Therapeutics Inc. N/A 92337R101 5256.00000000 NS USD 123831.36000000 0.426068771711 Long EC CORP US N 1 N N N Vericel Corporation 54930076YM3PLTDR4B91 92346J108 3463.00000000 NS USD 147350.65000000 0.506992012818 Long EC CORP US N 1 N N N Moderna Inc 549300EI6OKH5K5Q2G38 60770K107 25263.00000000 NS USD 697006.17000000 2.398201576137 Long EC CORP US N 1 N N N Janux Therapeutics Inc N/A 47103J105 3422.00000000 NS USD 79048.20000000 0.271982553369 Long EC CORP US N 1 N N N AnaptysBio Inc. 529900HH4WQT03IG1A12 032724106 1957.00000000 NS USD 43445.40000000 0.149483363620 Long EC CORP US N 1 N N N Agios Pharmaceuticals Inc 529900ONJHY8EOGYT555 00847X104 3603.00000000 NS USD 119835.78000000 0.412321108253 Long EC CORP US N 1 N N N Exact Sciences Corporation 549300VM3X1FYD4N9Z14 30063P105 12595.00000000 NS USD 669298.30000000 2.302866613026 Long EC CORP US N 1 N N N Myriad Genetics Inc. 52990044IHUOUMETT163 62855J104 8237.00000000 NS USD 43738.47000000 0.150491734803 Long EC CORP US N 1 N N N Veracyte Inc 529900ESWZRHXOW27Z37 92337F107 7936.00000000 NS USD 214510.08000000 0.738068662940 Long EC CORP US N 1 N N N Immunovant Inc N/A 45258J102 7765.00000000 NS USD 124240.00000000 0.427474786656 Long EC CORP US N 1 N N N Vaxcyte Inc 254900M7NMHTGASX8D95 92243G108 12020.00000000 NS USD 390770.20000000 1.344530005448 Long EC CORP US N 1 N N N Acadia Pharmaceuticals Inc 529900O3044NO0PEA039 004225108 9170.00000000 NS USD 197796.90000000 0.680563326053 Long EC CORP US N 1 N N N Protagonist Therapeutics Inc N/A 74366E102 5874.00000000 NS USD 324655.98000000 1.117049628037 Long EC CORP US N 1 N N N Gilead Sciences Inc. 549300WTZWR07K8MNV44 375558103 6414.00000000 NS USD 711120.18000000 2.446763902390 Long EC CORP US N 1 N N N Amicus Therapeutics Inc. 549300MRD1SMUTNBPQ53 03152W109 30268.00000000 NS USD 173435.64000000 0.596743103732 Long EC CORP US N 1 N N N Ardelyx Inc 549300F542QR4SXHCY32 039697107 26217.00000000 NS USD 102770.64000000 0.353604776308 Long EC CORP US N 1 N N N Incyte Corporation. 549300Z4WN6JVZ3T4680 45337C102 10182.00000000 NS USD 693394.20000000 2.385773806456 Long EC CORP US N 1 N N N N/A N/A N/A 159.00000000 OU USD 5430.34000000 0.018684267812 Long DE US N 2 GOLDMAN SACHS GROUP, INC. 784F5XWPLTWKTBV3E584 DOW JONES U.S. BIOTECHNOLOGY INDEX SPSIBI Index This swap is not based on custom baskets or indices Y DOW JONES U.S. BIOTECHNOLOGY INDEX 2025-07-23 0.00000000 USD 0.00000000 USD 1027025.52000000 USD 5430.34000000 N N N Bridgebio Pharma Inc 54930028YG89VTY2J114 10806X102 14351.00000000 NS USD 619676.18000000 2.132130898598 Long EC CORP US N 1 N N N Disc Medicine Inc N/A 254604101 2296.00000000 NS USD 121596.16000000 0.418378079155 Long EC CORP US N 1 N N N Apogee Therapeutics Inc. N/A 03770N101 3078.00000000 NS USD 133677.54000000 0.459946699068 Long EC CORP US N 1 N N N Mannkind Corporation 213800GFBCNY1ZFST722 56400P706 17160.00000000 NS USD 64178.40000000 0.220819766967 Long EC CORP US N 1 N N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 558868105 1789.00000000 NS USD 541422.96000000 1.862883647111 Long EC CORP US N 1 N N N Ionis Pharmaceuticals, Inc. 549300SI4ZGLG0BLUZ92 462222100 10558.00000000 NS USD 417146.58000000 1.435283687139 Long EC CORP US N 1 N N N Uniqure N.V. 724500RPCTZLFYJZ3S98 N90064101 5018.00000000 NS USD 69950.92000000 0.240681379615 Long EC CORP NL N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 04280A100 10350.00000000 NS USD 163530.00000000 0.562660591291 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Incorporated 54930015RAQRRZ5ZGJ91 92532F100 1549.00000000 NS USD 689614.80000000 2.372769957384 Long EC CORP US N 1 N N N Rhythm Pharmaceuticals Inc 529900JPNWXQ8DPLA551 76243J105 3764.00000000 NS USD 237847.16000000 0.818364970846 Long EC CORP US N 1 N N N Anavex Life Sciences Corp. 549300K1I5L8COCQ8W36 032797300 6720.00000000 NS USD 61958.40000000 0.213181373322 Long EC CORP US N 1 N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 40637H109 13018.00000000 NS USD 677196.36000000 2.330041609110 Long EC CORP US N 1 N N N Akebia Therapeutics Inc. 549300CBQEHMKEEGNX42 00972D105 18520.00000000 NS USD 67412.80000000 0.231948424806 Long EC CORP US N 1 N N N Cogent Biosciences Inc. N/A 19240Q201 6685.00000000 NS USD 47998.30000000 0.165148607955 Long EC CORP US N 1 N N N Caredx Inc 549300NQOFKL9NON0U06 14167L103 5205.00000000 NS USD 101705.70000000 0.349940618233 Long EC CORP US N 1 N N N Immunome Inc N/A 45257U108 5572.00000000 NS USD 51819.60000000 0.178296623105 Long EC CORP US N 1 N N N Biomarin Pharmaceutical Inc. NSLL8ITTRR0J5HEMR848 09061G101 12265.00000000 NS USD 674207.05000000 2.319756236810 Long EC CORP US N 1 N N N Regenxbio Inc. 549300EOES47LATSET33 75901B107 4423.00000000 NS USD 36312.83000000 0.124942202649 Long EC CORP US N 1 N N N Beam Therapeutics Inc. N/A 07373V105 8958.00000000 NS USD 152375.58000000 0.524281379203 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc 549300FECER0XBN49756 64125C109 5646.00000000 NS USD 709645.74000000 2.441690770351 Long EC CORP US N 1 N N N 2025-06-30 ProFund VP Biotechnology Rebecca Colvin Rebecca Colvin Treasurer and Principal Financial Officer