<?xml version="1.0" encoding="UTF-8"?><!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com --><!-- Created: Fri Sep 11 17:31:46 UTC 2026 --><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:common="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001140361-26-034749</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001039765</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Stock, $0.0001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/03/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0000034956</issuerCik>
        <issuerName>Tenax Therapeutics, Inc.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>88032L605</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <common:street1>101 Glen Lennox Drive</common:street1>
          <common:street2>Suite 300, Chapel Hill</common:street2>
          <common:city>North Carolina</common:city>
          <common:stateOrCountry>X1</common:stateOrCountry>
          <common:zipCode>27517</common:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>ING Groep N.V.</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>0</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.00</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <comments>* Based on the 37,423,917 shares of common stock of the issuer (the "Common Stock") as of July 28, 2026, as reported in the issuer's Quarterly Report on Form 10-Q for the period ended in June 30, 2026, filed with the Securities and Exchange Commission on July 31, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>ING Capital Markets LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>0</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.00</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>* Based on the 37,423,917 shares of common stock of the issuer (the "Common Stock") as of July 28, 2026, as reported in the issuer's Quarterly Report on Form 10-Q for the period ended in June 30, 2026, filed with the Securities and Exchange Commission on July 31, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Tenax Therapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>101 Glen Lennox Drive, Suite 300, Chapel Hill, North Carolina 27517, USA</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>ING Groep, N.V.
ING Capital Markets LLC</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>ING Groep N.V.
PO Box 1800
Amsterdam, P7
1000 BV Amsterdam

ING Capital Markets LLC
1133 Avenue of the Americas
New York, NY 10036
USA</principalBusinessOfficeOrResidenceAddress>
        <citizenship>ING Groep N.V. - The Netherlands

ING Capital Markets LLC - Delaware</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>As of September 11, 2026, none of the Reporting Persons beneficially owned any Common Stock.</amountBeneficiallyOwned>
        <classPercent>As of September 11, 2026, none of the Reporting Persons beneficially owned any percentage of the Common Stock issued and outstanding as of July 28, 2026, as reported in the issuer's Quarterly Report on Form 10-Q for the period ended in June 30, 2026, filed with the Securities and Exchange Commission on July 31, 2026.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>ING Groep N.V.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Bianca Jennifer Dobrescu</signature>
        <title>Bianca Jennifer Dobrescu/Authorized Representative</title>
        <date>09/11/2026</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Ioana Adriana Barbu</signature>
        <title>Ioana Adriana Barbu/Authorized Representative</title>
        <date>09/11/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ING Capital Markets LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Anthony Masciangelo</signature>
        <title>Anthony Masciangelo/Director</title>
        <date>09/11/2026</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Tim Casady</signature>
        <title>Tim Casady/Authorized Person</title>
        <date>09/11/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
