<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001088875-21-000042</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001088875</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>12</amendmentNo>
      <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001038683</issuerCik>
        <issuerName>RYANAIR HOLDINGS PLC</issuerName>
        <issuerCusip>783513203</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>C/O RYANAIR LTD CORPORATE HEAD OFFICE</com:street1>
          <com:street2>DUBLIN AIRPORT</com:street2>
          <com:city>COUNTY DUBLIN IRELAND</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
          <com:zipCode>3538444440</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>BAILLIE GIFFORD &amp; CO</reportingPersonName>
      <citizenshipOrOrganization>X0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>38806125.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>50982025.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>50982025.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>4.8</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>RYANAIR HOLDINGS PLC</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>C/O RYANAIR LTD CORPORATE HEAD OFFICE, DUBLIN AIRPORT, COUNTY DUBLIN IRELAND, IRELAND, 3538444440.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Baillie Gifford &amp; Co</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Calton Square

1 Greenside Row

Edinburgh

EH1 3AN

Scotland

UK</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Scotland</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>FI</typeOfPersonFiling>
        <otherTypeOfPersonFiling>Investment Adviser </otherTypeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>50,982,025
These are held as 12,885,805 ordinary shares and 19,048,110 American Depositary Shares [ADS] with each ADS representing 2 ordinary Shares.</amountBeneficiallyOwned>
        <classPercent>4.79</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>38,806,125
These are held as 11,325,049 ordinary shares and 13,740,538 American Depositary Shares [ADS] with each ADS representing 2 ordinary Shares.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0.00</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>50,982,025
These are held as 12,885,805 ordinary shares and 19,048,110 American Depositary Shares [ADS] with each ADS representing 2 ordinary Shares.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0.00</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ? 240.14a-11.

By signing below I certify that, to the best of my knowledge and belief, the foreign regulatory scheme applicable to Investment Adviser is substantially comparable to the regulatory scheme applicable to the functionally equivalent U.S. institution(s). I also undertake to furnish to the Commission staff, upon request, information that would otherwise be disclosed in a Schedule 13D.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>BAILLIE GIFFORD &amp; CO</reportingPersonName>
      <signatureDetails>
        <signature>Grant Meikle</signature>
        <title>Threshold &amp; Transaction Reporting Manager</title>
        <date>04/29/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
