Sale of Common Stock (Details) $ / shares in Units, $ in Thousands												1 Months Ended	12 Months Ended
	Oct. 22, 2021 USD ($) shares	Oct. 22, 2021 shares	Oct. 08, 2021 $ / shares shares	Jul. 09, 2021 USD ($)	Mar. 15, 2021 USD ($) shares	Mar. 15, 2021 shares	Mar. 05, 2021 $ / shares shares	Feb. 02, 2021 USD ($)	Aug. 24, 2020 USD ($) D $ / shares shares	Mar. 09, 2020 USD ($) $ / shares shares	Mar. 03, 2020 $ / shares shares	Mar. 31, 2020 $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) shares	Sep. 01, 2021 USD ($)
Subsidiary, Sale of Stock [Line Items]
Maximum offering from universal shelf registration | $				$ 500,000				$ 500,000
Term of securities offered under self registration				3 years				3 years
Sale of common stock (in shares) | shares					1,927,049				1
Proceeds from sale of common stock | $					$ 108,676								$ 261,477	$ 27,281
Exercise price | $ / shares									$ 58.70				$ 58.70
Proceeds from the Securities Purchase Agreement | $									$ 26,799
Number of warrants exercised | shares									515,747
Stock options granted (in shares) | shares													0	111,258,000
Exercise of stock options (shares) | shares													29,559,000	54,930,000
Proceeds from exercise of stock options | $													$ 442	$ 212
2009 Stock Option Plan
Subsidiary, Sale of Stock [Line Items]
Stock options granted (in shares) | shares											48,000	49,061	0
Exercise price (in dollars per share) | $ / shares											$ 45.98	$ 44.99
2020 Incentive Award Plan
Subsidiary, Sale of Stock [Line Items]
Stock options granted (in shares) | shares											52,000	53,149
Exercise price (in dollars per share) | $ / shares										$ 46.91	$ 46.91	$ 45.90
Exercise of stock options (shares) | shares										53,293
Proceeds from exercise of stock options | $										$ 2,500
Public Offering [Member]
Subsidiary, Sale of Stock [Line Items]
Sale of common stock (in shares) | shares							1,750,000
Share price | $ / shares							$ 56.85
Over-Allotment Option [Member]
Subsidiary, Sale of Stock [Line Items]
Sale of common stock (in shares) | shares	293,228	2,443,228	2,150,000			177,049
Share price | $ / shares			$ 62.70
Proceeds from sale of common stock | $	$ 152,801
Securities Purchase Agreement
Subsidiary, Sale of Stock [Line Items]
Sale of common stock (in shares) | shares									504,590
Share price | $ / shares									$ 50.00
Minimum period to nominate member to board of directors									24 months
Additional shares of common stock | shares									504,590
Exercise price | $ / shares									$ 60.00
Warrant Price | $ / shares									$ 4.00
Proceeds from the Securities Purchase Agreement | $									$ 26,799
Percentage of ownership interest									4.90%
Contingent Value Rights Agreement [Member]
Subsidiary, Sale of Stock [Line Items]
Percentage of warrants									9.90%
Proceeds from the Securities Purchase Agreement | $									$ 1,342
Warrant Term									3 years
Trading days | D									30
Contingent Value Rights Agreement [Member] | Received Minimum Sixty One Days Prior Notice from Holder
Subsidiary, Sale of Stock [Line Items]
Percentage of warrants									19.90%
Increase (Decrease) in beneficial ownership interest									61 days
At The Market Offering [Member]
Subsidiary, Sale of Stock [Line Items]
Aggregate gross sale offering amount | $															$ 100,000
Common Stock
Subsidiary, Sale of Stock [Line Items]
Proceeds from the Securities Purchase Agreement | $									$ 20,542
Warrant
Subsidiary, Sale of Stock [Line Items]
Proceeds from the Securities Purchase Agreement | $									$ 4,915