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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities:    
Net loss $ (39,241) $ (33,158)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 8,631 9,608
Depreciation 68 121
Loss on disposal of property and equipment   12
Amortization of operating lease right-of-use asset 350  
Amortization of debt discount 378  
Amortization of premium and discount on investment (228)  
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (150) (401)
Other assets   (41)
Advances from collaboration partners 403  
Accounts payable 940 (178)
Accrued expenses (856) 1,730
Operating lease liabilities (350)  
Taxes payable (79)  
Net cash used in operating activities (30,134) (22,307)
Cash flows from investing activities:    
Purchases of marketable securities (56,041)  
Proceeds from maturity of marketable securities 13,500 6
Purchases of property and equipment (40) (133)
Cash paid for long-term deposits (22) (11)
Net cash used in investing activities (42,603) (138)
Cash flows from financing activities:    
Proceeds from debt financing obligation 15,000  
Payment of debt issuance costs (276)  
Payment for settlement of taxes upon vesting of restricted stock securities (1,215)  
Proceeds from issuance of common stock on share-based compensation arrangements 148 103
Net cash provided by financing activities 46,281 53,676
(Decrease) increase in cash, cash equivalents and restricted cash (26,456) 31,231
Cash, cash equivalents and restricted cash, beginning of period 48,651 24,151
Cash, cash equivalents and restricted cash, end of period 22,195 55,382
Reconciliation of cash, cash equivalents and restricted cash to condensed consolidated balance sheets    
Cash and cash equivalents 22,155 55,336
Restricted cash included in restricted bank deposit 40 46
Total cash, cash equivalents and restricted cash 22,195 55,382
Supplemental disclosure of cash flow activities    
Cash paid for interest 703  
Cash paid for income taxes 79  
Capital expenditures in liabilities for purchases of property, plant and equipment   104
Supplemental disclosure of non-cash financing activities    
Non-cash acquisition of treasury shares 46 83
Non-cash issuance of shares upon exercise of warrants 178  
Fair value of warrants issued in connection with long-term debt 421  
Underwritten Public Offering [Member]    
Cash flows from financing activities:    
Proceeds from issuance of common stock 32,169 $ 53,573
Equity Sales Agreement [Member]    
Cash flows from financing activities:    
Proceeds from issuance of common stock $ 455