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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 NFo2isJ2i3b0IzAt+eVeI01A9CEmk68PP86RD5I2tOnujtPBVsES6/XyWAJ1NAMG
 awdjpEUT9X3HBr0ZDlGewA==

<SEC-DOCUMENT>0001179110-08-021405.txt : 20081223
<SEC-HEADER>0001179110-08-021405.hdr.sgml : 20081223
<ACCEPTANCE-DATETIME>20081223083304
ACCESSION NUMBER:		0001179110-08-021405
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081219
FILED AS OF DATE:		20081223
DATE AS OF CHANGE:		20081223

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GALTON BRUCE C
		CENTRAL INDEX KEY:			0001211403

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31326
		FILM NUMBER:		081265606

	MAIL ADDRESS:	
		STREET 1:		C/O SENESCO TECHNOLOGIES INC
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08901

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SENESCO TECHNOLOGIES INC
		CENTRAL INDEX KEY:			0001035354
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				841368850
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		34 CHAMBERS STREET
		STREET 2:		PO BOX 3303
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08542
		BUSINESS PHONE:		6092520880

	MAIL ADDRESS:	
		STREET 1:		303 GEORGE STREET
		STREET 2:		SUITE 420
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08901

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NAVA LEISURE USA INC
		DATE OF NAME CHANGE:	19970310
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-12-19</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001035354</issuerCik>
        <issuerName>SENESCO TECHNOLOGIES INC</issuerName>
        <issuerTradingSymbol>SNT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001211403</rptOwnerCik>
            <rptOwnerName>GALTON BRUCE C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>303 GEORGE STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 420</rptOwnerStreet2>
            <rptOwnerCity>NEW BRUNSWICK</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08901</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2008-12-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>.65</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>294480</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares which were sold pursuant to a 10b-5 Plan.  Such shares were originally acquired through the automatic grant of Restricted Stock Units, pursuant to the Company's Short Term Incentive Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Bruce C. Galton</signatureName>
        <signatureDate>2008-12-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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