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Advances From Collaboration Partners, Legal and Other Contingencies - Additional Information (Detail)
$ in Thousands
1 Months Ended 3 Months Ended
Mar. 31, 2022
USD ($)
May 31, 2021
USD ($)
Mar. 31, 2023
USD ($)
Time
Dec. 31, 2022
USD ($)
Advances from collaboration partners     $ 12,535 $ 12,535
Royalties percentage of net sales based on actual amount of funding     6.00%  
Maximum [Member]        
Related party transaction percentage of expenses     5.00%  
Two Thousand Nineteen Cystic Fibrosis Foundation Award [Member]        
Advances from collaboration partners     $ 11,900 11,900
Two Thousand Nineteen Cystic Fibrosis Foundation Award [Member] | Maximum [Member]        
Funding award amount received     $ 3,600  
Two Thousand Twenty Two Cystic Fibrosis Foundation Agreement [Member]        
Number of times amount of funds received | Time     3  
Two Thousand Twenty Two Cystic Fibrosis Foundation Agreement [Member] | Elox - Liabilities [Member]        
Advances from collaboration partners     $ 58 45
Embedded derivative, gain (loss) on embedded derivative, net     $ 13  
Two Thousand Twenty Two Cystic Fibrosis Foundation Agreement [Member] | Elox - Cystic Fibrosis Foundation [Member]        
Percentage Of Consideration Received For Disposition Event     10.00%  
Two Thousand Twenty Two Cystic Fibrosis Foundation Agreement [Member] | Elox - Cystic Fibrosis Foundation [Member] | Elox - Phase Two Clinical Development [Member]        
Remaining amount of award payable upon achievement certain clinical development milestones     $ 7,400  
Two Thousand Twenty Two Cystic Fibrosis Foundation Agreement [Member] | Elox - Cystic Fibrosis Foundation [Member] | Elox - Phase Two Clinical Development [Member] | Maximum [Member]        
Award to fund development milestones $ 15,900      
Two Thousand Twenty One Cystic Fibrosis Foundation Award [Member]        
Advances from collaboration partners     $ 600 $ 600
Two Thousand Twenty One Cystic Fibrosis Foundation Award [Member] | Maximum [Member]        
Funding award amount received   $ 2,600    
Two Thousand Twenty One Cystic Fibrosis Foundation Award [Member] | Elox - Cystic Fibrosis Foundation [Member]        
Percentage Of Consideration Received For Disposition Event     20.00%  
Percentage of sale or license event     10.00%