Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2023

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Transactions Related to Stock Options Awarded to Employees and Directors

Transactions related to stock options awarded to employees and directors during the three months ended March 31, 2023 were as follows:

	Shares			Weighted average exercise price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
Options outstanding at December 31, 2022		249,403		$	105.87		8.12	$	3
Granted		195,895			4.27
Forfeited		(15,638	)		22.41
Options outstanding at March 31, 2023		429,660		$	62.59		6.77	$	10
Options exercisable at March 31, 2023		109,601		$	171.38		7.26	$	10

Summary of Allocated Stock-based Compensation Expense

Total stock-based compensation expense related to all of the Company’s stock-based awards was recognized as follows (in thousands):

	Three Months Ended March 31,
	2023		2022
Research and development	$	288	$	360
General and administrative		309		562
Total stock-based compensation expense	$	597	$	922