X0101 EFFECT 33 LIVE 2017-12-28 0000067590-17-001411 485APOS 0001035018 PRUDENTIAL INVESTMENT PORTFOLIOS, INC. 10 333-119741 S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000005598 CLASS A S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000005599 CLASS B S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000005600 CLASS C S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000060787 CLASS Z S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000095828 CLASS Q S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000150230 Class R S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000198542 Class R2 S000002179 PRUDENTIAL QMA MID-CAP VALUE FUND C000198543 Class R4