X0306 4 2021-12-16 0 0001034842 RIGEL PHARMACEUTICALS INC RIGL 0001654337 Ali-Jackson Kamil RIGEL PHARMACEUTICALS, INC. 1180 VETERANS BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Option (Right to Buy) 2.44 2021-12-16 4 A 0 120000 0 A 2031-12-16 Common Stock 120000 120000 D The option shall vest in equal monthly installments over the shorter of three years from the date of grant or the period beginning on the date the Reporting Person was appointed to the Company's Board of Directors and ending on the date of the annual meeting at which the Reporting Person is first considered for election by the stockholders, provided that the Reporting Person continues to provide service. /s/ Dolly Vance (Attorney-in-Fact) 2021-12-17