DOCUMENT AND ENTITY INFORMATION Statement [Table] Statement [Line Items] Statement Document Type Document Annual Report Document Fiscal Period Focus Current Fiscal Year End Date Document Period End Date Document Transition Report Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company ICFR Auditor Attestation Flag Document Financial Statement Error Correction [Flag] Entity Shell Company Entity Central Index Key Amendment Flag Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Auditor Name Auditor Firm ID Auditor Location BALANCE SHEETS Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Short-term Investments Short-term investments Accounts Receivable, Net, Current Accounts receivable Accounts receivable, net Inventory, Net Inventories Prepaid Expense and Other Assets, Current Prepaid and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Intangible Assets, Net (Including Goodwill) Intangible assets, net Intangible asset Operating Lease, Right-of-Use Asset Operating lease right-of-use asset Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity (deficit) Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation Represents the carrying value as of the balance sheet date of research and development costs that are incurred but not billed to the entity as of the end of the period. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Research and Development Liability Current Accrued research and development Contract with Customer, Refund Liability, Current Revenue reserves and refund liability Loans Payable, Current Loans payable, net, current portion Other Accrued Liabilities, Current Other accrued liabilities Total other accrued liabilities Contract with Customer, Liability, Current Deferred revenue Operating Lease, Liability, Current Lease liabilities, current portion Other Liabilities, Current Other long-term liabilities, current portion Liabilities, Current Total current liabilities Asset Acquisition, Contingent Consideration, Liability, Noncurrent Acquisition-related liabilities Operating Lease, Liability, Noncurrent Long-term portion of lease liabilities Loans Payable, Noncurrent Long-term portion of loans payable, net Long-term portion of loans payable, net Other Liabilities, Noncurrent Other long-term liabilities Liabilities Total liabilities Commitment and Contingencies Commitments Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity (deficit): Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 10,000,000 shares authorized; none issued and outstanding as of December 31, 2024 and 2023 Common Stock, Value, Issued Common stock, $0.001 par value; 400,000,000 shares authorized; 17,710,216 and 17,482,513 shares issued and outstanding as of December 31, 2024 and 2023, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Balance Balance Total stockholders' equity (deficit) Liabilities and Equity Total liabilities and stockholders' equity (deficit) Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Shares Authorized Common stock, shares authorized Authorized number of shares of common stock Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Stockholders' Equity Note, Stock Split, Conversion Ratio Stock split, conversion ratio STATEMENTS OF OPERATIONS Product and Service [Axis] Product and Service [Domain] Product sales, net Represents contract revenues from collaborations. Contract revenues from collaborations Government contracts Revenue Total revenues Costs and Expenses [Abstract] Costs and expenses: Less: Cost of Goods and Services Sold Cost of product sales Research and Development Expense (Excluding Acquired in Process Cost) Research and development Selling, General and Administrative Expense Selling, general and administrative Restructure charges Restructuring charges Costs and Expenses Total costs and expenses Operating Income (Loss) Income (loss) from operations Investment Income, Interest Interest income Interest Expense Interest expense Interest expense Income (Loss) Attributable to Parent, before Tax Income (loss) before income taxes Provision for income taxes Net income (loss) Net income loss per share abstract. Net Income Loss Per Share [Abstract] Net income (loss) per share Net income (loss) per share Earnings Per Share, Basic Basic (in dollars per share) Earnings Per Share, Diluted Diluted (in dollars per share) Weighted average shares used in computing net income loss per share abstract. Weighted Average Shares Used In Computing Net Income Loss Per Share [Abstract] Weighted average shares used in computing net income (loss) per share Weighted-average common shares outstanding, Basic Basic (in shares) Weighted-average common shares outstanding (in shares) Weighted-average shares outstanding and common stock equivalents Diluted (in shares) Weighted-average shares outstanding and common stock equivalents (in shares) STATEMENTS OF COMPREHENSIVE INCOME (LOSS) Net Income (Loss) Available to Common Stockholders, Basic Net income (loss) Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Net unrealized gain on short-term investments Net change in unrealized gain (loss) on short-term investments Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive income (loss) STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) Equity Components [Axis] Equity Component [Domain] Common Stock Additional Paid-in Capital Accumulated Other Comprehensive Income (Loss) Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Shares, Issued Balance (in shares) Balance (in shares) Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Issuance of common stock upon exercise of options and participation in Purchase Plan Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Issuance of common stock upon vesting of RSUs Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Issuance of common stock upon vesting of RSUs (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net income (loss) Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net income (loss) to net cash provided by operating activities: Share-based Compensation Stock-based compensation expense Gain (Loss) on Disposition of Assets (Gain) loss on sale and disposal of fixed assets Depreciation, Depletion and Amortization Depreciation and amortization Noncash interest expense during the period. Noncash Interest Expense Non-cash interest expense Investment Income, Net, Amortization of Discount and Premium Net amortization of discount on short-term investments and term loans Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable, net Increase (Decrease) in Inventories Inventories Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and other current and non-current assets Amount of increase or decrease in right-of-use assets. Increase Decrease Right Of Use Assets Right-of-use assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Employee Related Liabilities Accrued compensation Represents the increase (decrease) during the reporting period in the aggregate amount of research and development expenses incurred but not yet paid. Increase (Decrease) in Accrued Research and Development Liability Accrued research and development Represents the increase (decrease) during the reporting period in the aggregate amount of revenue reserves and refund liability. Revenue Reserves And Refund Liability Revenue reserves and refund liability Increase (Decrease) in Other Accrued Liabilities Other accrued liabilities Increase Decrease In Operating Lease Liability Lease liability Increase (Decrease) in Contract with Customer, Liability Deferred revenue Increase (Decrease) in Other Operating Liabilities Other current and long-term liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities Proceeds from Maturities, Prepayments and Calls of Short-term Investments Maturities of short-term investments Payments to Acquire Short-term Investments Purchases of short-term investments The cash outflow associated with the acquisition of capital expenditures. Payments To Acquire Capital Expenditures Capital expenditures Payments to Acquire Intangible Assets Payments for acquisition of intangible assets Proceeds from Sale of Property, Plant, and Equipment Proceeds from sale of property and equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities Proceeds from Long-term Lines of Credit Net proceeds from term loan financing Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options Net proceeds from issuance of common stock from equity plans Payment for Contingent Consideration Liability, Financing Activities Closing purchase price payment related to asset acquisition Payment of cost share to collaboration partner. Payment Of Cost Share To Collaboration Partner Cost share payments to a collaboration partner Payment of cost share to collaboration partner Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash (used in) provided by financing activities Net Cash Provided by (Used in) Continuing Operations Net increase in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash flow information Interest Paid, Excluding Capitalized Interest, Operating Activities Interest paid Income Taxes Paid, Net Income taxes paid Future cash outflow to pay for purchases of intangible assets that have occurred. Intangible Assets Incurred But Not Yet Paid Purchases of intangible asset included within accounts payable DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Business Description and Accounting Policies [Text Block] DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES NET INCOME (LOSS) PER SHARE Earnings Per Share [Text Block] NET INCOME (LOSS) PER SHARE REVENUES Revenues: Revenue from Contract with Customer [Text Block] REVENUES Corporate Collaborations SPONSORED RESEARCH AND LICENSE AGREEMENTS AND GOVERNMENT CONTRACTS Collaborative Arrangement Disclosure [Text Block] SPONSORED RESEARCH AND LICENSE AGREEMENTS AND GOVERNMENT CONTRACTS IN-LICENSING AND ACQUISITION Business Combination Disclosure [Text Block] IN-LICENSING AND ACQUISITION STOCK-BASED COMPENSATION Disclosure of Compensation Related Costs, Share-based Payments [Text Block] STOCK-BASED COMPENSATION INVENTORIES Inventory Disclosure [Text Block] INVENTORIES CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS Cash, Cash Equivalents, and Short-term Investments [Text Block] CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS FAIR VALUE Fair Value Disclosures [Text Block] FAIR VALUE OTHER BALANCE SHEET COMPONENTS Supplemental Balance Sheet Disclosures [Text Block] OTHER BALANCE SHEET COMPONENTS DEBT Debt Disclosure [Text Block] DEBT COMMITMENTS AND CONTINGENCIES