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  <xsd:element id="rigl_SubleaseAgreementAbstract" name="SubleaseAgreementAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_CorporateCollaborationsDisclosureAbstract" name="CorporateCollaborationsDisclosureAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ControlledEquityOfferingTable" name="ControlledEquityOfferingTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ControlledEquityOfferingLineItems" name="ControlledEquityOfferingLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_MaximumAvailableUnderControlledEquityOffering" name="MaximumAvailableUnderControlledEquityOffering" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_InducementPlanMember" name="InducementPlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeOneMember" name="ExercisePriceRangeOneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeFourMember" name="ExercisePriceRangeFourMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeFiveMember" name="ExercisePriceRangeFiveMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeSixMember" name="ExercisePriceRangeSixMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ExercisePriceRangeSevenMember" name="ExercisePriceRangeSevenMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ChargebacksDiscountsAndFeesMember" name="ChargebacksDiscountsAndFeesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_GovernmentAndOtherRebatesMember" name="GovernmentAndOtherRebatesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ContractRevenuesFromCollaborationsMember" name="ContractRevenuesFromCollaborationsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_MckessonSpecialtyCareDistributionCorporationMember" name="MckessonSpecialtyCareDistributionCorporationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_DevelopmentMilestonesMember" name="DevelopmentMilestonesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_GrossProductMember" name="GrossProductMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_DiscountsAndAllowancesMember" name="DiscountsAndAllowancesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_GrifolsS.a.Member" name="GrifolsS.a.Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_FostamatinibMember" name="FostamatinibMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_RoyaltyPaymentAsPercentageOfNetSales" name="RoyaltyPaymentAsPercentageOfNetSales" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_KisseiPharmaceuticalCo.Ltd.Member" name="KisseiPharmaceuticalCo.Ltd.Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_SpecifiedCommercialMilestonesMember" name="SpecifiedCommercialMilestonesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_EuropeanMedicinesAgencyApprovalOfFostamatinibForTreatmentOfChronicImmuneThrombocytopenicPurpuraMember" name="EuropeanMedicinesAgencyApprovalOfFostamatinibForTreatmentOfChronicImmuneThrombocytopenicPurpuraMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_EquityIncentivePlan2018Member" name="EquityIncentivePlan2018Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_AccountsReceivableAndPrepaidAndOtherCurrentAssetsMember" name="AccountsReceivableAndPrepaidAndOtherCurrentAssetsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_CashFlowInformationRelatedToOperatingLeaseTableTextBlock" name="CashFlowInformationRelatedToOperatingLeaseTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_FixedSubleaseExpense" name="FixedSubleaseExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_VariableSubleaseExpense" name="VariableSubleaseExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_NetSubleaseIncomeExpense" name="NetSubleaseIncomeExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="rigl_MedisonPharmaLtd.Member" name="MedisonPharmaLtd.Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_CreditableAdvanceRoyaltyPaymentMember" name="CreditableAdvanceRoyaltyPaymentMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_OperatingSubleaseInformationTableTextBlock" name="OperatingSubleaseInformationTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_CommercialAndLicenseAgreementMember" name="CommercialAndLicenseAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_LicensedRightsMember" name="LicensedRightsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_OneTimeDeliveryOfDrugSupplyForCommercializationMember" name="OneTimeDeliveryOfDrugSupplyForCommercializationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_DevelopmentCostsCostSharingArrangementPercentage" name="DevelopmentCostsCostSharingArrangementPercentage" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_IncreaseDecreaseRightOfUseAssets" name="IncreaseDecreaseRightOfUseAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_CustomerAllowanceForPromptPaymentDiscounts" name="CustomerAllowanceForPromptPaymentDiscounts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="rigl_DevelopmentAndRegulatoryMilestonesByNonCentralNervousSystemDiseaseProductsMember" name="DevelopmentAndRegulatoryMilestonesByNonCentralNervousSystemDiseaseProductsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_DevelopmentAndRegulatoryMilestonesByCentralNervousSystemDiseaseProductsMember" name="DevelopmentAndRegulatoryMilestonesByCentralNervousSystemDiseaseProductsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_MilestonePaymentsOnProductByProductBasisMember" name="MilestonePaymentsOnProductByProductBasisMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_CustomerAllowanceForPromptPaymentDiscountsTableTextBlock" name="CustomerAllowanceForPromptPaymentDiscountsTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_CustomerAllowanceForPromptPaymentDiscountsPeriodIncrease" name="CustomerAllowanceForPromptPaymentDiscountsPeriodIncrease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="rigl_CustomerAllowanceForPromptPaymentDiscountsPeriodDecrease" name="CustomerAllowanceForPromptPaymentDiscountsPeriodDecrease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_NoncashInterestExpense" name="NoncashInterestExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="rigl_GovernmentContractPolicyPolicyTextBlock" name="GovernmentContractPolicyPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_NonCentralNervousSystemPenetrantIntellectualPropertyMember" name="NonCentralNervousSystemPenetrantIntellectualPropertyMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ShareBasedCompensationOptionsAndRsusMember" name="ShareBasedCompensationOptionsAndRsusMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_FinancingLiabilityIncludingInterestExpenseAccretion" name="FinancingLiabilityIncludingInterestExpenseAccretion" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="rigl_FinancingLiabilityInterestAccretionDiscountRate" name="FinancingLiabilityInterestAccretionDiscountRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_PaymentOfCostShareToCollaborationPartner" name="PaymentOfCostShareToCollaborationPartner" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" abstract="false" />
  <xsd:element id="rigl_NumberOfActiveEquityPlans" name="NumberOfActiveEquityPlans" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingRollForward" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingRollForward" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsGranted" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsGranted" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsAuthorizedForGrantNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsAuthorizedForGrantNumber" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsCancelledAndForfeited" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsCancelledAndForfeited" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LiquidityAndCapitalResourcesPolicyPolicyTextBlock" id="rigl_LiquidityAndCapitalResourcesPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RestructuringPolicyPolicyTextBlock" id="rigl_RestructuringPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DueToCollaborationPartner" id="rigl_DueToCollaborationPartner" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="KnightTherapeuticsInternationalSaMember" id="rigl_KnightTherapeuticsInternationalSaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DevelopmentAndRegulatoryMilestonesMember" id="rigl_DevelopmentAndRegulatoryMilestonesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FormaTherapeuticsHoldingsIncMember" id="rigl_FormaTherapeuticsHoldingsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementUpfrontPayment" id="rigl_CollaborativeArrangementUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementPotentialPayments" id="rigl_CollaborativeArrangementPotentialPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedOrReleasedInPeriod" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedOrReleasedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedOrReleasedWeightedAverageGrantDateFairValue" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedOrReleasedWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AccruedCommercialExpensesCurrent" id="rigl_AccruedCommercialExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AccruedOtherExpensesCurrent" id="rigl_AccruedOtherExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenueReservesAndRefundLiability" id="rigl_RevenueReservesAndRefundLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RezlidhiaMember" id="rigl_RezlidhiaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="HeadquartersOfficeSpaceSubleaseSouthSanFranciscoCaliforniaMember" id="rigl_HeadquartersOfficeSpaceSubleaseSouthSanFranciscoCaliforniaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IntangibleAssetsIncurredButNotYetPaid" id="rigl_IntangibleAssetsIncurredButNotYetPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AchievementOfCertainNearTermRegulatoryMilestoneMember" id="rigl_AchievementOfCertainNearTermRegulatoryMilestoneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FdaApprovalAndFirstCommercialSaleOfProductMember" id="rigl_FdaApprovalAndFirstCommercialSaleOfProductMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DepreciationAndAmortizationExpense" id="rigl_DepreciationAndAmortizationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RoyaltyDeliveryOfDrugSuppliesAndOthersMember" id="rigl_RoyaltyDeliveryOfDrugSuppliesAndOthersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RightToOptOutOfAgreementNumberOfPeriods" id="rigl_RightToOptOutOfAgreementNumberOfPeriods" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AmendedLillyAgreementMember" id="rigl_AmendedLillyAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AgreementOptOutRightExerciseTerm" id="rigl_AgreementOptOutRightExerciseTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InventoryAndInventoryReportedAsOtherAssets" id="rigl_InventoryAndInventoryReportedAsOtherAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InventoryReportedAsOtherAssets" id="rigl_InventoryReportedAsOtherAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InventoryAndInventoryReportedAsOtherAssetsAbstract" id="rigl_InventoryAndInventoryReportedAsOtherAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtPrincipalOutstandingNetOfUnamortizedDebtIssuanceCosts" id="rigl_DebtPrincipalOutstandingNetOfUnamortizedDebtIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="BiomedicalAdvancedResearchAndDevelopmentAuthorityMember" id="rigl_BiomedicalAdvancedResearchAndDevelopmentAuthorityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StrategicCollaborationAgreementWithMdAndersonMember" id="rigl_StrategicCollaborationAgreementWithMdAndersonMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StrategicCollaborationAgreementWithConnectMember" id="rigl_StrategicCollaborationAgreementWithConnectMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationTerm" id="rigl_CollaborationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GavretoMember" id="rigl_GavretoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstCommercialSaleMember" id="rigl_FirstCommercialSaleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstAnniversaryOfClosingDateMember" id="rigl_FirstAnniversaryOfClosingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BlueprintMedicinesCorporationMember" id="rigl_BlueprintMedicinesCorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PotentialMilestonePaymentObligations" id="rigl_PotentialMilestonePaymentObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PotentialTieredRoyaltyPercentage" id="rigl_PotentialTieredRoyaltyPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="UnrecognizedTaxBenefitsDecreasesResultingFromEvaluationOfPriorOrphanDrugCredits" id="rigl_UnrecognizedTaxBenefitsDecreasesResultingFromEvaluationOfPriorOrphanDrugCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RegulatoryMilestonesMember" id="rigl_RegulatoryMilestonesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FollowingFourthAmendmentMember" id="rigl_FollowingFourthAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetPurchaseAgreementDrugProductInventories" id="rigl_AssetPurchaseAgreementDrugProductInventories" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockholdersEquityReverseStockSplitPolicyPolicyTextBlock" id="rigl_StockholdersEquityReverseStockSplitPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CardinalHealthIncMember" id="rigl_CardinalHealthIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CencoraIncMember" id="rigl_CencoraIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OcadusertibMember" id="rigl_OcadusertibMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SublicenseRevenueFeeMember" id="rigl_SublicenseRevenueFeeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NetIncomeLossPerShareAbstract" id="rigl_NetIncomeLossPerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WeightedAverageSharesUsedInComputingNetIncomeLossPerShareAbstract" id="rigl_WeightedAverageSharesUsedInComputingNetIncomeLossPerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CumulativeShareOfDevelopmentCostsLimit" id="rigl_CumulativeShareOfDevelopmentCostsLimit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PaymentsToAcquireCapitalExpenditures" id="rigl_PaymentsToAcquireCapitalExpenditures" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="Dr.ReddysLaboratoriesLtd.Member" id="rigl_Dr.ReddysLaboratoriesLtd.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnitedStatesCustomersMember" id="rigl_UnitedStatesCustomersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationPartnersMember" id="rigl_CollaborationPartnersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OffBalanceSheetContractualObligationsSubjectToCancellationFees" id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueWithinOneYear" id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueWithinOneYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueInSecondAndThirdYear" id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueInSecondAndThirdYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CancellationFeesUnderAgreementsWithContractManufacturers" id="rigl_CancellationFeesUnderAgreementsWithContractManufacturers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationOrphanDrugAndResearchAndDevelopmentCredits" id="rigl_EffectiveIncomeTaxRateReconciliationOrphanDrugAndResearchAndDevelopmentCredits" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementStrategyAndGovernanceAbstract" id="rigl_CybersecurityRiskManagementStrategyAndGovernanceAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CybersecurityRiskManagementProcessesForAssessingIdentifyingAndManagingThreatsTextBlock" id="rigl_CybersecurityRiskManagementProcessesForAssessingIdentifyingAndManagingThreatsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskBoardOfDirectorsOversightTextBlock" id="rigl_CybersecurityRiskBoardOfDirectorsOversightTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementProcessesIntegratedFlag" id="rigl_CybersecurityRiskManagementProcessesIntegratedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementProcessesIntegratedTextBlock" id="rigl_CybersecurityRiskManagementProcessesIntegratedTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementThirdPartyEngagedFlag" id="rigl_CybersecurityRiskManagementThirdPartyEngagedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskThirdPartyOversightAndIdentificationProcessesFlag" id="rigl_CybersecurityRiskThirdPartyOversightAndIdentificationProcessesFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskMateriallyAffectedOrReasonablyLikelyToMateriallyAffectRegistrantFlag" id="rigl_CybersecurityRiskMateriallyAffectedOrReasonablyLikelyToMateriallyAffectRegistrantFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock" id="rigl_CybersecurityRiskBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskProcessForInformingBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock" id="rigl_CybersecurityRiskProcessForInformingBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskRoleOfManagementTextBlock" id="rigl_CybersecurityRiskRoleOfManagementTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementPositionsOrCommitteesResponsibleFlag" id="rigl_CybersecurityRiskManagementPositionsOrCommitteesResponsibleFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementPositionsOrCommitteesResponsibleTextBlock" id="rigl_CybersecurityRiskManagementPositionsOrCommitteesResponsibleTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementExpertiseOfManagementResponsibleTextBlock" id="rigl_CybersecurityRiskManagementExpertiseOfManagementResponsibleTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskProcessForInformingManagementOrCommitteesResponsibleTextBlock" id="rigl_CybersecurityRiskProcessForInformingManagementOrCommitteesResponsibleTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CybersecurityRiskManagementPositionsOrCommitteesResponsibleReportToBoardFlag" id="rigl_CybersecurityRiskManagementPositionsOrCommitteesResponsibleReportToBoardFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SegmentReportingOtherItemAmount" id="rigl_SegmentReportingOtherItemAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SingleReportableSegmentMember" id="rigl_SingleReportableSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommercialRelatedExpenses" id="rigl_CommercialRelatedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OutsideClinicalTrialRelatedExpenses" id="rigl_OutsideClinicalTrialRelatedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ConsultantsAndThirdPartyServicesExpense" id="rigl_ConsultantsAndThirdPartyServicesExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AociDebtSecuritiesAvailableForSaleWithoutAllowanceForCreditLossCumulativeLossAfterTax" id="rigl_AociDebtSecuritiesAvailableForSaleWithoutAllowanceForCreditLossCumulativeLossAfterTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
</xsd:schema>
