X0303 4 2011-02-23 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 929 NORTH FRONT STREET WILMINGTON NC 28401 1 1 0 0 Executive Chairman Common Stock 7050871 D Common Stock 409500 I GRAT Common Stock 11258 I LLC Common Stock 1685 I Spouse Stock Options (to buy) 27.27 2011-02-23 4 A 0 90000 0 A 2012-02-23 2021-02-23 Common Stock 90000 90000 D Restricted Stock Units 2011-02-23 4 A 0 30000 0 A Common Stock 30000 30000 D Stock Options (to buy) 20.45 2011-02-25 2020-02-25 Common Stock 103506 103506 D Stock Options (to buy) 25.74 2010-02-18 2019-02-18 Common Stock 103506 103506 D Stock Options (to buy) 19.94 2009-11-20 2018-11-20 Common Stock 51753 51753 D Stock Options (to buy) 43.26 2009-02-20 2018-02-20 Common Stock 103506 103506 D Stock Options (to buy) 32.47 2008-02-21 2017-02-20 Common Stock 51753 51753 D Stock Options (to buy) 33.44 2007-02-22 2016-02-21 Common Stock 207012 207012 D Stock Options (to buy) 20.47 2005-11-16 2014-11-15 Common Stock 258764 258764 D Stock Options (to buy) 14.78 2006-12-03 2013-12-02 Common Stock 124207 124207 D Stock Options (to buy) 14.44 2005-12-03 2012-12-02 Common Stock 41403 41403 D The options vest in equal increments of 1/3 each on 2/23/12, 2/23/13 and 2/23/14. Each restricted stock unit (RSU) represents a contingent right to receive one share of PPDI common stock. These RSUs vest in three equal installments on 2/23/12, 2/23/13 and 2/23/14. Unvested RSUs are forfeited at termination of employment. The options vest in equal increments of 1/3 each on 2/25/11, 2/25/12 and 2/25/13. The options were awarded on 2/18/09 and vest in three equal increments on 2/18/10, 2/18/11 and 2/18/12. The options were awarded on 11/20/08 and vest as follows: 16,666 on 11/20/09, 16,667 on 11/20/10 and 16,667 on 11/20/11. The options were awarded on 2/20/08 and vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2011-02-25