X0303 4 2010-09-15 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 929 NORTH FRONT STREET WILMINGTON NC 28401 1 1 0 0 Executive Chairman Common Stock 2010-09-15 5 G 0 75000 0 D 7022871 D Common Stock 2010-09-29 5 G 0 62500 0 D 6960371 D Common Stock 2010-09-29 5 J 0 37500 0 D 462500 I GRAT Common Stock 2010-09-29 5 J 0 37500 0 A 6997871 D Common Stock 2010-10-25 5 J 0 38000 0 D 424500 I GRAT Common Stock 2010-10-25 5 J 0 38000 0 A 7035871 D Common Stock 11258 I LLC Common Stock 1685 I Spouse Stock Options (to buy) 20.45 2011-02-25 2020-02-25 Common Stock 103506 103506 D Stock Options (to buy) 25.74 2010-02-18 2019-02-18 Common Stock 103506 103506 D Stock Options (to buy) 19.94 2009-11-20 2018-11-20 Common Stock 51753 51753 D Stock Options (to buy) 43.26 2009-02-20 2018-02-20 Common Stock 103506 103506 D Stock Options (to buy) 32.47 2008-02-21 2017-02-20 Common Stock 51753 51753 D Stock Options (to buy) 33.44 2007-02-22 2016-02-21 Common Stock 207012 207012 D Stock Options (to buy) 20.47 2005-11-16 2014-11-15 Common Stock 258764 258764 D Stock Options (to buy) 14.78 2006-12-03 2013-12-02 Common Stock 124207 124207 D Stock Options (to buy) 14.44 2005-12-03 2012-12-02 Common Stock 41403 41403 D The Reporting Person made two gifts of stock in late September. The Reporting Person made two transfers from his Grantor Retained Annuity Trust, shown as an indirect holding, to himself in late September and late October. Exercise price and share amounts reflect an anti-dilution adjustment made in connection with the June 14, 2010 spin-off of Furiex Pharmaceuticals, Inc. The options were awarded on 2/25/10 and vest in three equal increments on 2/25/11, 2/25/12 and 2/25/13. The options were awarded on 2/18/09 and vest in three equal increments on 2/18/08, 2/18/09 and 2/18/10. The options were awarded on 11/20/08 and vest as follows: 16,666 on 11/20/09, 16,667 on 11/20/10 and 16,667 on 11/20/11. The options were awarded on 2/20/08 and vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2010-11-02