X0303 4 2010-04-13 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 929 NORTH FRONT STREET WILMINGTON NC 28401 1 1 0 0 Executive Chairman Common Stock 2010-04-13 5 G 0 100000 0 D 7144368 D Common Stock 2010-04-27 5 G 0 10000 0 D 7134368 D Common Stock 2010-05-03 5 G 0 36497 0 D 7097871 D Common Stock 500000 I GRAT Common Stock 11258 I LLC Common Stock 1685 I Spouse Stock Options (to buy) 21.17 2011-02-25 2020-02-25 Common Stock 100000 100000 D Stock Options (to buy) 26.64 2010-02-18 2019-02-18 Common Stock 100000 100000 D Stock Options (to buy) 20.64 2009-11-20 2018-11-20 Common Stock 50000 50000 D Stock Options (to buy) 44.78 2009-02-20 2018-02-20 Common Stock 100000 100000 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 15.30 2006-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D The options were awarded on 2/25/10 and vest in three equal increments on 2/25/11, 2/25/12 and 2/25/13. The options were awarded on 2/18/09 and vest in three equal increments on 2/18/08, 2/18/09 and 2/18/10. The options were awarded on 11/20/08 and vest as follows: 16,666 on 11/20/09, 16,667 on 11/20/10 and 16,667 on 11/20/11. The options were awarded on 2/20/08 and vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2010-05-21