X0202 4 2008-05-20 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2008-05-20 4 S 0 4100 42.63 D 8079746 D Common Stock 2008-05-20 4 S 0 2270 42.64 D 8077476 D Common Stock 2008-05-20 4 S 0 5900 42.65 D 8071576 D Common Stock 2008-05-20 4 S 0 1600 42.66 D 8069976 D Common Stock 2008-05-20 4 S 0 1200 42.68 D 8068776 D Common Stock 2008-05-20 4 S 0 1000 42.69 D 8067776 D Common Stock 2008-05-20 4 S 0 8620 42.70 D 8059156 D Common Stock 2008-05-20 4 S 0 9200 42.71 D 8049956 D Common Stock 2008-05-20 4 S 0 2324 42.72 D 8047632 D Common Stock 2008-05-20 4 S 0 5525 42.73 D 8042107 D Common Stock 2008-05-20 4 S 0 3000 42.74 D 8039107 D Common Stock 2008-05-20 4 S 0 7202 42.75 D 8031905 D Common Stock 2008-05-20 4 S 0 6475 42.76 D 8025430 D Common Stock 2008-05-20 4 S 0 1900 42.77 D 8023530 D Common Stock 2008-05-20 4 S 0 1000 42.78 D 8022530 D Common Stock 2008-05-20 4 S 0 2406 42.79 D 8020124 D Common Stock 2008-05-20 4 S 0 1498 42.80 D 8018626 D Common Stock 2008-05-21 4 S 0 2400 43.53 D 8016226 D Common Stock 2008-05-21 4 S 0 600 43.54 D 8015626 D Common Stock 2008-05-21 4 S 0 7000 43.55 D 8008626 D Common Stock 2008-05-21 4 S 0 1500 43.56 D 8007126 D Common Stock 2008-05-21 4 S 0 1875 43.57 D 8005251 D Common Stock 2008-05-21 4 S 0 600 43.58 D 8004651 D Common Stock 2008-05-21 4 S 0 25 43.60 D 8004626 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2006-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 44.78 2009-02-20 2018-02-19 Common Stock 100000 100000 D The options were awarded on 2/20/08 and vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This is 2 of 2 Forms 4 being filed to report sales of stock on May 19-21, 2008. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2008-05-21