X0202 4 2008-05-19 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2008-05-19 4 S 0 2197 43.11 D 8152429 D Common Stock 2008-05-19 4 S 0 5503 43.10 D 8146926 D Common Stock 2008-05-19 4 S 0 3804 43.12 D 8143122 D Common Stock 2008-05-19 4 S 0 2000 43.11 D 8141122 D Common Stock 2008-05-19 4 S 0 100 43.03 D 8141022 D Common Stock 2008-05-19 4 S 0 396 43.02 D 8140626 D Common Stock 2008-05-19 4 S 0 1000 43.05 D 8139626 D Common Stock 2008-05-19 4 S 0 1438 43.07 D 8138188 D Common Stock 2008-05-19 4 S 0 290 43.09 D 8137898 D Common Stock 2008-05-19 4 S 0 800 43.08 D 8137098 D Common Stock 2008-05-19 4 S 0 2762 43.06 D 8134336 D Common Stock 2008-05-19 4 S 0 1900 43.01 D 8132436 D Common Stock 2008-05-19 4 S 0 5098 43.00 D 8127338 D Common Stock 2008-05-19 4 S 0 1012 43.02 D 8126326 D Common Stock 2008-05-19 4 S 0 1900 42.93 D 8124426 D Common Stock 2008-05-19 4 S 0 2055 42.92 D 8122371 D Common Stock 2008-05-19 4 S 0 5000 42.90 D 8117371 D Common Stock 2008-05-19 4 S 0 445 42.87 D 8116926 D Common Stock 2008-05-19 4 S 0 1100 42.91 D 8115826 D Common Stock 2008-05-19 4 S 0 778 42.86 D 8115048 D Common Stock 2008-05-19 4 S 0 300 42.84 D 8114748 D Common Stock 2008-05-19 4 S 0 122 42.83 D 8114626 D Common Stock 2008-05-20 4 S 0 8100 42.52 D 8106526 D Common Stock 2008-05-20 4 S 0 3600 42.53 D 8102926 D Common Stock 2008-05-20 4 S 0 5700 42.55 D 8095286 D Common Stock 2008-05-20 4 S 0 1400 42.57 D 8095826 D Common Stock 2008-05-20 4 S 0 3400 42.59 D 8092426 D Common Stock 2008-05-20 4 S 0 2042 42.60 D 8090384 D Common Stock 2008-05-20 4 S 0 638 42.61 D 8089746 D Common Stock 2008-05-20 4 S 0 5900 42.62 D 8083846 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2006-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 44.78 2009-02-20 2018-02-19 Common Stock 100000 100000 D The options were awarded on 2/20/08 and vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This is 1 of 2 Forms 4 being filed to report sales of stock on May 19-21, 2008. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2008-05-21