X0202 4 2007-12-27 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-12-27 4 J 0 100000 0 D 8154626 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. The Reporting Person was awarded 100,000 shares of restricted stock on December 5, 2007, but on December 27, 2007, rescinded all rights to that stock. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-12-28