X0202 4 2007-07-16 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-07-16 4 S 0 404 38.99 D 8354226 D Common Stock 2007-07-16 4 S 0 496 39.00 D 8353730 D Common Stock 2007-07-16 4 S 0 504 39.01 D 8353226 D Common Stock 2007-07-16 4 S 0 560 39.02 D 8352666 D Common Stock 2007-07-16 4 S 0 740 39.03 D 8351926 D Common Stock 2007-07-16 4 S 0 600 39.04 D 8351326 D Common Stock 2007-07-16 4 S 0 500 39.05 D 8350826 D Common Stock 2007-07-16 4 S 0 100 39.06 D 8350726 D Common Stock 2007-07-16 4 S 0 100 39.10 D 8350626 D This Form 4 is 4 of 4 Forms 4 being filed to report the sale of stock on July 16, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-07-17