X0202 4 2007-07-16 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-07-16 4 S 0 100 37.99 D 8433860 D Common Stock 2007-07-16 4 S 0 92 38.06 D 8433768 D Common Stock 2007-07-16 4 S 0 8 38.07 D 8433760 D Common Stock 2007-07-16 4 S 0 100 38.09 D 8433660 D Common Stock 2007-07-16 4 S 0 100 38.11 D 8433560 D Common Stock 2007-07-16 4 S 0 500 38.12 D 8433060 D Common Stock 2007-07-16 4 S 0 700 38.13 D 8432360 D Common Stock 2007-07-16 4 S 0 1337 38.14 D 8431023 D Common Stock 2007-07-16 4 S 0 2697 38.15 D 8428326 D Common Stock 2007-07-16 4 S 0 2200 38.16 D 8426126 D Common Stock 2007-07-16 4 S 0 400 38.17 D 8425726 D Common Stock 2007-07-16 4 S 0 500 38.18 D 8425226 D Common Stock 2007-07-16 4 S 0 600 38.19 D 8424626 D Common Stock 2007-07-16 4 S 0 500 38.20 D 8424126 D Common Stock 2007-07-16 4 S 0 100 38.21 D 8424026 D Common Stock 2007-07-16 4 S 0 200 38.22 D 8423826 D Common Stock 2007-07-16 4 S 0 900 38.23 D 8422926 D Common Stock 2007-07-16 4 S 0 1700 38.24 D 8421226 D Common Stock 2007-07-16 4 S 0 600 38.25 D 8420626 D Common Stock 2007-07-16 4 S 0 400 38.26 D 8420226 D Common Stock 2007-07-16 4 S 0 500 38.27 D 8419726 D Common Stock 2007-07-16 4 S 0 300 38.28 D 8419426 D Common Stock 2007-07-16 4 S 0 200 38.29 D 8419226 D Common Stock 2007-07-16 4 S 0 300 38.30 D 8418926 D Common Stock 2007-07-16 4 S 0 200 38.31 D 8418726 D Common Stock 2007-07-16 4 S 0 300 38.32 D 8418426 D Common Stock 2007-07-16 4 S 0 300 38.33 D 8418126 D Common Stock 2007-07-16 4 S 0 400 38.34 D 8417726 D Common Stock 2007-07-16 4 S 0 100 38.35 D 8417626 D Common Stock 2007-07-16 4 S 0 100 38.36 D 8417526 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 1 of 4 Forms 4 being filed to report the sale of stock on July 16, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-07-17