X0202 4 2007-05-14 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-05-14 4 S 0 100 33.48 D 8767194 D Common Stock 2007-05-14 4 S 0 1900 33.49 D 8765294 D Common Stock 2007-05-14 4 S 0 2570 33.50 D 8762724 D Common Stock 2007-05-14 4 S 0 3664 33.51 D 8759060 D Common Stock 2007-05-14 4 S 0 1500 33.52 D 8757560 D Common Stock 2007-05-14 4 S 0 2300 33.53 D 8755260 D Common Stock 2007-05-14 4 S 0 6700 33.54 D 8748560 D Common Stock 2007-05-14 4 S 0 5200 33.55 D 8743360 D Common Stock 2007-05-14 4 S 0 1915 33.56 D 8741445 D Common Stock 2007-05-14 4 S 0 2685 33.57 D 8738760 D Common Stock 2007-05-14 4 S 0 5410 33.58 D 8733350 D Common Stock 2007-05-14 4 S 0 6290 33.59 D 8727060 D Common Stock 2007-05-14 4 S 0 5300 33.60 D 8721760 D Common Stock 2007-05-14 4 S 0 4200 33.61 D 8717560 D Common Stock 2007-05-14 4 S 0 2400 33.62 D 8715160 D Common Stock 2007-05-14 4 S 0 1100 33.63 D 8714060 D Common Stock 2007-05-14 4 S 0 900 33.64 D 8713160 D Common Stock 2007-05-14 4 S 0 892 33.65 D 8712268 D Common Stock 2007-05-14 4 S 0 2600 33.66 D 8709668 D Common Stock 2007-05-14 4 S 0 1062 33.67 D 8708606 D Common Stock 2007-05-14 4 S 0 854 33.68 D 8707752 D Common Stock 2007-05-14 4 S 0 1692 33.69 D 8706060 D Common Stock 2007-05-14 4 S 0 500 33.70 D 8705560 D Common Stock 2007-05-14 4 S 0 3100 33.71 D 8702460 D Common Stock 2007-05-14 4 S 0 1398 33.72 D 8701062 D Common Stock 2007-05-14 4 S 0 2702 33.73 D 8698360 D Common Stock 2007-05-14 4 S 0 2400 33.74 D 8695960 D Common Stock 2007-05-14 4 S 0 100 33.75 D 8695860 D Common Stock 2007-05-14 4 S 0 1900 33.76 D 8693960 D Common Stock 2007-05-14 4 S 0 1000 33.78 D 8692960 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 1 of 2 Forms 4 being filed to report the sale of stock on May 14, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-05-15