X0202 4 2007-04-16 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-04-16 4 S 0 400 34.36 D 8909760 D Common Stock 2007-04-16 4 S 0 600 34.37 D 8909160 D Common Stock 2007-04-16 4 S 0 1200 34.38 D 8907960 D Common Stock 2007-04-16 4 S 0 1700 34.39 D 8906260 D Common Stock 2007-04-16 4 S 0 1000 34.40 D 8905260 D Common Stock 2007-04-16 4 S 0 500 34.41 D 8904760 D Common Stock 2007-04-16 4 S 0 100 34.42 D 8904660 D Common Stock 2007-04-16 4 S 0 100 34.43 D 8904560 D Common Stock 2007-04-16 4 S 0 100 34.44 D 8904460 D Common Stock 2007-04-16 4 S 0 200 34.45 D 8904260 D Common Stock 2007-04-16 4 S 0 600 34.48 D 8903660 D Common Stock 2007-04-16 4 S 0 200 34.49 D 8903460 D Common Stock 2007-04-16 4 S 0 600 34.50 D 8902860 D Common Stock 2007-04-16 4 S 0 200 34.51 D 8902660 D Common Stock 2007-04-16 4 S 0 200 34.52 D 8902460 D Common Stock 2007-04-16 4 S 0 1100 34.53 D 8901360 D Common Stock 2007-04-16 4 S 0 1400 34.54 D 8899960 D Common Stock 2007-04-16 4 S 0 100 34.55 D 8899860 D Common Stock 2007-04-16 4 S 0 200 34.57 D 8899660 D Common Stock 2007-04-16 4 S 0 1900 34.58 D 8897760 D Common Stock 2007-04-16 4 S 0 4500 34.59 D 8893260 D Common Stock 2007-04-16 4 S 0 1400 34.60 D 8891860 D Common Stock 2007-04-16 4 S 0 4300 34.61 D 8887560 D Common Stock 2007-04-16 4 S 0 300 34.62 D 8887260 D Common Stock 2007-04-16 4 S 0 200 34.63 D 8887060 D Common Stock 2007-04-16 4 S 0 200 34.64 D 8886860 D Common Stock 2007-04-16 4 S 0 2500 34.65 D 8884360 D Common Stock 2007-04-16 4 S 0 4000 34.66 D 8880360 D Common Stock 2007-04-16 4 S 0 2600 34.67 D 8877760 D Common Stock 2007-04-16 4 S 0 2400 34.68 D 8875360 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 2 of 3 Forms 4 being filed to report the sale of stock on April 16, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-04-18