X0202 4 2007-04-02 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-04-02 4 S 0 500 33.40 D 9016793 D Common Stock 2007-04-02 4 S 0 100 33.48 D 9016693 D Common Stock 2007-04-02 4 S 0 300 33.49 D 9016393 D Common Stock 2007-04-02 4 S 0 200 33.50 D 9016193 D Common Stock 2007-04-02 4 S 0 1092 33.51 D 9015101 D Common Stock 2007-04-02 4 S 0 4208 33.52 D 9010893 D Common Stock 2007-04-02 4 S 0 5199 33.53 D 9005694 D Common Stock 2007-04-02 4 S 0 3100 33.54 D 9002594 D Common Stock 2007-04-02 4 S 0 7390 33.55 D 8995204 D Common Stock 2007-04-02 4 S 0 3811 33.56 D 8991393 D Common Stock 2007-04-02 4 S 0 3683 33.57 D 8987710 D Common Stock 2007-04-02 4 S 0 6017 33.58 D 8981693 D Common Stock 2007-04-02 4 S 0 7200 33.59 D 8974493 D Common Stock 2007-04-02 4 S 0 7300 33.60 D 8967193 D Common Stock 2007-04-02 4 S 0 1909 33.61 D 8965284 D Common Stock 2007-04-02 4 S 0 5619 33.62 D 8959665 D Common Stock 2007-04-02 4 S 0 4100 33.63 D 8955565 D Common Stock 2007-04-02 4 S 0 4772 33.64 D 8950793 D Common Stock 2007-04-02 4 S 0 3980 33.65 D 8946813 D Common Stock 2007-04-02 4 S 0 6707 33.66 D 8940106 D Common Stock 2007-04-02 4 S 0 2618 33.67 D 8937488 D Common Stock 2007-04-02 4 S 0 2195 33.68 D 8935293 D Common Stock 2007-04-02 4 S 0 933 33.69 D 8934360 D Common Stock 2007-04-02 4 S 0 200 33.70 D 8934160 D Common Stock 2007-04-02 4 S 0 200 33.74 D 8933960 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is filed to report the sale of stock on April 2, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-04-03