X0202 4 2007-03-19 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-03-19 4 S 0 401 31.41 D 9100226 D Common Stock 2007-03-19 4 S 0 99 31.43 D 9100127 D Common Stock 2007-03-19 4 S 0 500 31.52 D 9099627 D Common Stock 2007-03-19 4 S 0 1300 31.53 D 9098327 D Common Stock 2007-03-19 4 S 0 1800 31.54 D 9096527 D Common Stock 2007-03-19 4 S 0 400 31.55 D 9096127 D Common Stock 2007-03-19 4 S 0 100 31.56 D 9096027 D Common Stock 2007-03-19 4 S 0 1800 31.57 D 9094227 D Common Stock 2007-03-19 4 S 0 100 31.58 D 9194127 D Common Stock 2007-03-19 4 S 0 1100 31.59 D 9093027 D Common Stock 2007-03-19 4 S 0 7041 31.60 D 9085986 D Common Stock 2007-03-19 4 S 0 6859 31.61 D 9079127 D Common Stock 2007-03-19 4 S 0 5000 31.62 D 9074127 D Common Stock 2007-03-19 4 S 0 3500 31.63 D 9070627 D Common Stock 2007-03-19 4 S 0 1700 31.64 D 9068927 D Common Stock 2007-03-19 4 S 0 6934 31.65 D 9061993 D Common Stock 2007-03-19 4 S 0 4166 31.66 D 9057827 D Common Stock 2007-03-19 4 S 0 4687 31.67 D 9053140 D Common Stock 2007-03-19 4 S 0 3213 31.68 D 9049927 D Common Stock 2007-03-19 4 S 0 1500 31.69 D 9048427 D Common Stock 2007-03-19 4 S 0 4500 31.70 D 9043927 D Common Stock 2007-03-19 4 S 0 900 31.71 D 9043027 D Common Stock 2007-03-19 4 S 0 2000 31.72 D 9041027 D Common Stock 2007-03-19 4 S 0 2334 31.73 D 9038693 D Common Stock 2007-03-19 4 S 0 1000 31.74 D 9037693 D Common Stock 2007-03-19 4 S 0 6801 31.75 D 9030892 D Common Stock 2007-03-19 4 S 0 5199 31.76 D 9025693 D Common Stock 2007-03-19 4 S 0 5018 31.77 D 9020675 D Common Stock 2007-03-19 4 S 0 2182 31.78 D 9018493 D Common Stock 2007-03-19 4 S 0 900 31.79 D 9017593 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options were awarded on 2/20/07 and vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 1 of 2 Forms 4 being filed to report the sale of stock on March 19, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-03-20