X0202 4 2007-03-01 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-03-01 4 S 0 76 31.06 D 9183884 D Common Stock 2007-03-01 4 S 0 232 31.12 D 9183652 D Common Stock 2007-03-01 4 S 0 92 31.13 D 9183560 D Common Stock 2007-03-01 4 S 0 100 31.15 D 9183460 D Common Stock 2007-03-01 4 S 0 500 31.16 D 9182960 D Common Stock 2007-03-01 4 S 0 1100 31.17 D 9181860 D Common Stock 2007-03-01 4 S 0 500 31.18 D 9181360 D Common Stock 2007-03-01 4 S 0 200 31.19 D 9181160 D Common Stock 2007-03-01 4 S 0 900 31.20 D 9180260 D Common Stock 2007-03-01 4 S 0 700 31.21 D 9179560 D Common Stock 2007-03-01 4 S 0 106 31.22 D 9179454 D Common Stock 2007-03-01 4 S 0 894 31.23 D 9178560 D Common Stock 2007-03-01 4 S 0 700 31.24 D 9177860 D Common Stock 2007-03-01 4 S 0 1400 31.25 D 9176460 D Common Stock 2007-03-01 4 S 0 500 31.26 D 9175960 D Common Stock 2007-03-01 4 S 0 400 31.27 D 9175560 D Common Stock 2007-03-01 4 S 0 300 31.28 D 9175260 D Common Stock 2007-03-01 4 S 0 1600 31.29 D 9173660 D Common Stock 2007-03-01 4 S 0 2600 31.30 D 9171060 D Common Stock 2007-03-01 4 S 0 1400 31.31 D 9169660 D Common Stock 2007-03-01 4 S 0 2300 31.32 D 9167360 D Common Stock 2007-03-01 4 S 0 500 31.33 D 9166860 D Common Stock 2007-03-01 4 S 0 1600 31.34 D 9165260 D Common Stock 2007-03-01 4 S 0 2500 31.35 D 9162760 D Common Stock 2007-03-01 4 S 0 6000 31.36 D 9156760 D Common Stock 2007-03-01 4 S 0 4058 31.37 D 9152702 D Common Stock 2007-03-01 4 S 0 3655 31.38 D 9149047 D Common Stock 2007-03-01 4 S 0 7987 31.39 D 9141060 D Common Stock 2007-03-01 4 S 0 4600 31.40 D 9136460 D Common Stock 2007-03-01 4 S 0 4633 31.41 D 9131827 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 1 of 2 Forms 4 being filed to report the sale of stock on March 1, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-03-05