X0202 4 2007-02-26 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-02-26 4 S 0 100 32.65 D 9267193 D Common Stock 2007-02-26 4 S 0 500 32.66 D 9266693 D Common Stock 2007-02-26 4 S 0 500 32.67 D 9266193 D Common Stock 2007-02-26 4 S 0 500 32.68 D 9265693 D Common Stock 2007-02-26 4 S 0 500 32.69 D 9265193 D Common Stock 2007-02-26 4 S 0 1000 32.70 D 9264193 D Common Stock 2007-02-26 4 S 0 700 32.71 D 9263493 D Common Stock 2007-02-26 4 S 0 1000 32.72 D 9262493 D Common Stock 2007-02-26 4 S 0 800 32.73 D 9261693 D Common Stock 2007-02-26 4 S 0 700 32.74 D 9260993 D Common Stock 2007-02-26 4 S 0 2675 32.75 D 9258318 D Common Stock 2007-02-26 4 S 0 1600 32.76 D 9256718 D Common Stock 2007-02-26 4 S 0 1045 32.77 D 9255673 D Common Stock 2007-02-26 4 S 0 1213 32.78 D 9254460 D Common Stock 2007-02-26 4 S 0 8200 32.79 D 9246260 D Common Stock 2007-02-26 4 S 0 2300 32.80 D 9243960 D Common Stock 2007-02-26 4 S 0 1200 32.81 D 9242760 D Common Stock 2007-02-26 4 S 0 2400 32.82 D 9240360 D Common Stock 2007-02-26 4 S 0 3300 32.83 D 9237060 D Common Stock 2007-02-26 4 S 0 4400 32.84 D 9232660 D Common Stock 2007-02-26 4 S 0 400 32.85 D 9232260 D Common Stock 2007-02-26 4 S 0 1000 32.86 D 9231260 D Common Stock 2007-02-26 4 S 0 900 32.87 D 9230360 D Common Stock 2007-02-26 4 S 0 300 32.88 D 9230060 D Common Stock 2007-02-26 4 S 0 700 32.89 D 9229360 D Common Stock 2007-02-26 4 S 0 1100 32.90 D 9228260 D Common Stock 2007-02-26 4 S 0 500 32.91 D 9227760 D Common Stock 2007-02-26 4 S 0 1500 32.92 D 9226260 D Common Stock 2007-02-26 4 S 0 900 32.93 D 9225360 D Common Stock 2007-02-26 4 S 0 1600 32.94 D 9223760 D Stock Options (to buy) 33.61 2008-02-21 2017-02-20 Common Stock 50000 50000 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. The options vest as follows: 16,666 on 2/21/08, 16,667 on 2/21/09 and 16,667 on 2/21/10. This Form 4 is 1 of 3 Forms 4 being filed to report the sale of stock on February 26, 2007 pursuant to the 10b5-1 trading plan adopted by the Reporting Person. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-02-27