X0202 4 2007-02-20 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2007-02-20 4 S 0 9433 33.49 D 9282993 D Common Stock 2007-02-20 4 S 0 1100 33.50 D 9281893 D Common Stock 2007-02-20 4 S 0 1700 33.51 D 9280193 D Common Stock 2007-02-20 4 S 0 2600 33.52 D 9277593 D Common Stock 2007-02-20 4 S 0 300 33.53 D 9277293 D Common Stock 2007-02-20 4 S 0 5000 33.54 D 9272293 D Common Stock 2007-02-20 4 S 0 400 33.55 D 9271893 D Common Stock 2007-02-20 4 S 0 200 33.56 D 9271693 D Common Stock 2007-02-20 4 S 0 800 33.57 D 9270893 D Common Stock 2007-02-20 4 S 0 400 33.58 D 9270493 D Common Stock 2007-02-20 4 S 0 100 33.59 D 9270393 D Common Stock 2007-02-20 4 S 0 900 33.60 D 9269493 D Common Stock 2007-02-20 4 S 0 1300 33.61 D 9268193 D Common Stock 2007-02-20 4 S 0 900 33.62 D 9267293 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. This Form 4 is being filed along with another Form 4 to report sales being made pursuant to a 10b5-1 trading plan adopted by the Reporting Person. This is 2 of 2 reports being filed on February 21, 2007. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2007-02-21