X0202 4 2006-05-16 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2006-05-16 4 S 0 100 36.38 D 9505381 D Common Stock 2006-05-16 4 S 0 2000 36.40 D 9503381 D Common Stock 2006-05-16 4 S 0 500 36.41 D 9502881 D Common Stock 2006-05-16 4 S 0 2682 36.42 D 9500199 D Common Stock 2006-05-16 4 S 0 1071 36.43 D 9499128 D Common Stock 2006-05-16 4 S 0 2673 36.44 D 9496455 D Common Stock 2006-05-16 4 S 0 3326 36.45 D 9493129 D Common Stock 2006-05-16 4 S 0 1307 36.46 D 9491822 D Common Stock 2006-05-16 4 S 0 3797 36.47 D 9488025 D Common Stock 2006-05-16 4 S 0 2547 36.48 D 9485478 D Common Stock 2006-05-16 4 S 0 800 36.49 D 9484678 D Common Stock 2006-05-16 4 S 0 4910 36.50 D 9479768 D Common Stock 2006-05-16 4 S 0 4584 36.51 D 9475184 D Common Stock 2006-05-16 4 S 0 800 36.52 D 9474384 D Common Stock 2006-05-16 4 S 0 376 36.53 D 9474008 D Common Stock 2006-05-16 4 S 0 9300 36.54 D 9464708 D Common Stock 2006-05-16 4 S 0 2599 36.55 D 9462109 D Common Stock 2006-05-16 4 S 0 400 36.56 D 9461709 D Common Stock 2006-05-16 4 S 0 700 36.57 D 9461009 D Common Stock 2006-05-16 4 S 0 100 36.58 D 9460909 D Common Stock 2006-05-16 4 S 0 200 36.59 D 9460709 D Common Stock 2006-05-16 4 S 0 2240 36.60 D 9458469 D Common Stock 2006-05-16 4 S 0 1500 36.61 D 9456969 D Common Stock 2006-05-16 4 S 0 4100 36.62 D 9452869 D Common Stock 2006-05-16 4 S 0 384 36.63 D 9452485 D Common Stock 2006-05-16 4 S 0 1245 36.64 D 9451240 D Common Stock 2006-05-16 4 S 0 2660 36.65 D 9448580 D Common Stock 2006-05-16 4 S 0 424 36.66 D 9448156 D Common Stock 2006-05-16 4 S 0 3836 36.67 D 9444320 D Common Stock 2006-05-16 4 S 0 1614 36.68 D 9442706 D This report is being filed in conjunction with other Form 4s containing information regarding the sale of PPDI stock by the Reporting Person on May 16, 2006. This report is 2 of 3 reports being filed for May 16, 2006. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2006-05-17