X0202 4 2006-05-16 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 1 1 0 0 CEO Common Stock 2006-05-16 4 S 0 100 36.07 D 9577426 D Common Stock 2006-05-16 4 S 0 2800 36.08 D 9574626 D Common Stock 2006-05-16 4 S 0 600 36.09 D 9574026 D Common Stock 2006-05-16 4 S 0 2047 36.10 D 9571979 D Common Stock 2006-05-16 4 S 0 3000 36.11 D 9568979 D Common Stock 2006-05-16 4 S 0 1981 36.12 D 9566998 D Common Stock 2006-05-16 4 S 0 3926 36.13 D 9563072 D Common Stock 2006-05-16 4 S 0 9398 36.14 D 9553674 D Common Stock 2006-05-16 4 S 0 5525 36.15 D 9548149 D Common Stock 2006-05-16 4 S 0 3400 36.16 D 9544749 D Common Stock 2006-05-16 4 S 0 200 36.17 D 9544549 D Common Stock 2006-05-16 4 S 0 2704 36.18 D 9541845 D Common Stock 2006-05-16 4 S 0 200 36.19 D 9541645 D Common Stock 2006-05-16 4 S 0 3197 36.20 D 9538448 D Common Stock 2006-05-16 4 S 0 1358 36.21 D 9537090 D Common Stock 2006-05-16 4 S 0 411 36.22 D 9536679 D Common Stock 2006-05-16 4 S 0 300 36.23 D 9536379 D Common Stock 2006-05-16 4 S 0 194 36.24 D 9536185 D Common Stock 2006-05-16 4 S 0 2980 36.25 D 9533205 D Common Stock 2006-05-16 4 S 0 9684 36.26 D 9523521 D Common Stock 2006-05-16 4 S 0 600 36.27 D 9522921 D Common Stock 2006-05-16 4 S 0 8716 36.28 D 9514205 D Common Stock 2006-05-16 4 S 0 324 36.29 D 9513881 D Common Stock 2006-05-16 4 S 0 400 36.30 D 9513481 D Common Stock 2006-05-16 4 S 0 1200 36.31 D 9512281 D Common Stock 2006-05-16 4 S 0 2600 36.32 D 9509681 D Common Stock 2006-05-16 4 S 0 1400 36.33 D 9508281 D Common Stock 2006-05-16 4 S 0 2400 36.34 D 9505881 D Common Stock 2006-05-16 4 S 0 100 36.35 D 9505781 D Common Stock 2006-05-16 4 S 0 300 36.37 D 9505481 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/15/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. This report is being filed in conjunction with other Form 4s containing information regarding the sale of PPDI stock by the Reporting Person on May 16, 2006. This report is 1 of 3 reports being filed for May 16, 2006. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2006-05-17