X0202 4 2006-05-15 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001033409 ESHELMAN FREDRIC N 6814 TOWLES ROAD WILMINGTON NC 28409 0 1 0 0 CEO Common Stock 2006-05-15 4 S 0 1601 36.45 D 9828925 D Common Stock 2006-05-15 4 S 0 1300 36.48 D 9827625 D Common Stock 2006-05-15 4 S 0 3300 36.49 D 9824325 D Common Stock 2006-05-15 4 S 0 2799 36.52 D 9821526 D Common Stock 2006-05-15 4 S 0 83 36.53 D 9821443 D Common Stock 2006-05-15 4 S 0 908 36.61 D 9820535 D Common Stock 2006-05-15 4 S 0 3821 36.62 D 9816714 D Common Stock 2006-05-15 4 S 0 385 36.63 D 9816329 D Common Stock 2006-05-15 4 S 0 6800 36.64 D 9809529 D Common Stock 2006-05-15 4 S 0 3385 36.65 D 9806144 D Common Stock 2006-05-15 4 S 0 59079 36.66 D 9747065 D Common Stock 2006-05-15 4 S 0 43809 36.67 D 9703256 D Common Stock 2006-05-15 4 S 0 861 36.68 D 9702935 D Common Stock 2006-05-15 4 S 0 12500 36.69 D 9689895 D Common Stock 2006-05-15 4 S 0 19309 36.70 D 9670586 D Common Stock 2006-05-15 4 S 0 1096 36.71 D 9669490 D Common Stock 2006-05-15 4 S 0 4659 36.72 D 9664831 D Common Stock 2006-05-15 4 S 0 1340 36.73 D 9663491 D Common Stock 2006-05-15 4 S 0 6099 36.74 D 9657392 D Common Stock 2006-05-15 4 S 0 2100 36.75 D 9655292 D Common Stock 2006-05-15 4 S 0 1288 36.76 D 9654004 D Common Stock 2006-05-15 4 S 0 172 36.77 D 9653832 D Common Stock 2006-05-15 4 S 0 14040 36.78 D 9639792 D Common Stock 2006-05-15 4 S 0 711 36.79 D 9639081 D Common Stock 2006-05-15 4 S 0 1200 36.80 D 9637881 D Common Stock 2006-05-15 4 S 0 1600 36.81 D 9636281 D Common Stock 2006-05-15 4 S 0 600 36.82 D 9635681 D Common Stock 2006-05-15 4 S 0 3488 36.83 D 9632193 D Common Stock 2006-05-15 4 S 0 92 36.87 D 9632101 D Stock Options (to buy) 14.95 2005-12-03 2012-12-02 Common Stock 40000 40000 D Stock Options (to buy) 15.30 2004-12-03 2013-12-02 Common Stock 120000 120000 D Stock Options (to buy) 21.19 2005-11-16 2014-11-15 Common Stock 250000 250000 D Stock Options (to buy) 34.62 2007-02-22 2016-02-21 Common Stock 200000 200000 D The options were awarded on 12/3/03 and vest in three equal increments on 12/3/04, 12/3/05 and 12/3/06. The options were awarded on 11/16/04 and vest in four equal increments on 11/16/05, 11/16/06, 11/16/07 and 11/15/08. The options were awarded on 2/22/06 and vest in three equal increments on 2/22/07, 2/22/08 and 2/22/09. This report is being filed in conjunction with another Form 4 containing information regarding the sale of PPDI stock by the Reporting Person on May 15, 2006. This report is 1 of 2 reports being filed for May 15, 2006. Lisa C. Noecker attorney-in-fact for Fred N. Eshelman 2006-05-17