<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-01-01</periodOfReport>

    <issuer>
        <issuerCik>0001527469</issuerCik>
        <issuerName>Athene Holding Ltd</issuerName>
        <issuerTradingSymbol>ATH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001032681</rptOwnerCik>
            <rptOwnerName>ROWAN MARC J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ATHENE HOLDING LTD. SECOND FLOOR,</rptOwnerStreet1>
            <rptOwnerStreet2>WASHINGTON HOUSE, 16 CHURCH STREET</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Shares</value>
            </securityTitle>
            <transactionDate>
                <value>2022-01-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>681075</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Pursuant to the Agreement and Plan of Merger, dated March 8, 2021 (the &quot;Merger Agreement&quot;) by and among the Issuer, Apollo Global Management, Inc., a Delaware corporation (&quot;AGM&quot;), Tango Holdings, Inc., a Delaware corporation and a direct wholly owned subsidiary of AGM (&quot;HoldCo&quot;), Blue Merger Sub, Ltd., a Bermuda exempted company and a direct wholly owned subsidiary of HoldCo (&quot;Company Merger Sub&quot;), and Green Merger Sub, Inc., a Delaware corporation and a direct, wholly owned subsidiary of HoldCo (&quot;AGM Merger Sub&quot;), effective January 1, 2022 (the &quot;Effective Time&quot;): (i) AGM merged with AGM Merger Sub, with AGM surviving such merger as a direct wholly owned subsidiary of HoldCo (the &quot;AGM Merger&quot;), (ii) the Issuer merged with Company Merger Sub, with the Issuer surviving such merger as a direct, wholly owned subsidiary of HoldCo (the &quot;Company Merger&quot; and, together with the AGM Merger, the &quot;Mergers&quot;), and (iii) the name of HoldCo was changed to &quot;Apollo Global Management, Inc.&quot;</footnote>
        <footnote id="F2">Pursuant to the Merger Agreement, these Class A common shares, par value $0.001 per share, of the Issuer (&quot;Class A Common Shares&quot;) converted automatically into the right to receive 1.149 shares of common stock, par value $0.00001 per share, of HoldCo (&quot;HoldCo Shares&quot;), with fractional shares paid out in cash.  As of December 31, 2021, the closing market price of the Issuer's Class A Common Shares was $83.33 and the closing market price of AGM's Class A common stock was $72.43.</footnote>
        <footnote id="F3">By MJR Foundation LLC, an estate planning vehicle for which voting and investment control are exercised by the reporting person.</footnote>
    </footnotes>

    <remarks>Exhibit 24.1 - Power of Attorney (incorporated by reference to the Power of Attorney filed as Exhibit 24 to the Form 3 filed by the Reporting Person on December 9, 2016)</remarks>

    <ownerSignature>
        <signatureName>/s/ Ira Rosenblatt, attorney-in-fact</signatureName>
        <signatureDate>2022-01-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
