CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY - USD ($)	Preferred Stock	Common Stock	Additional Paid-In Capital	Accumulated Deficit	Total
Beginning balance, Value at Dec. 31, 2013	$ 27,496	$ 117,764	$ 132,192,648	$ (112,969,412)	$ 19,368,496
Beginning balance, Shares at Dec. 31, 2013	2,749,613	11,776,578
Proceeds from issuance of Common Stock and warrants, net, Value		$ 8,727	2,341,273		2,350,000
Proceeds from issuance of Common Stock and warrants, net, Shares		872,728
Fair value of Common Stock issued for services, Value		$ 26	8,378		8,404
Fair value of Common Stock issued for services, Shares		2,636
Issuance of Series F Preferred Stock and warrants, net of cash issuance costs, Value	$ 8,403		934,993		943,396
Issuance of Series F Preferred Stock and warrants, net of cash issuance costs, Shares	840,336
Capital contribution			440,675		440,675
Share-based compensation, net of restricted stock cancellations, Value		$ (222)	1,374,190		1,373,968
Share-based compensation, net of restricted stock cancellations, Shares		(22,247)
Net Loss				(14,962,654)	(14,962,654)
Ending Balance at Dec. 31, 2014	$ 35,899	$ 126,295	137,292,157	(127,932,066)	9,522,285
Ending Balance, Shares at Dec. 31, 2014	3,589,949	12,629,695
Exchange Common Stock for Series F, Value	$ 15,000	$ (15,000)			0
Exchange Common Stock for Series F, Shares	1,500,000	(1,500,000)
Issuance of Series F Preferred Stock and warrants, net of cash issuance costs, Value	$ 23,877		7,353,623		7,377,500
Issuance of Series F Preferred Stock and warrants, net of cash issuance costs, Shares	2,387,667
Capital contribution			59,325		59,325
Issuance of Series F pursuant to Reimbursement Agreement, Value	$ 5,482		1,796,518		1,802,000
Issuance of Series F pursuant to Reimbursement Agreement, Shares	548,177
Share-based compensation, net of restricted stock cancellations, Value		$ (52)	910,936		910,884
Share-based compensation, net of restricted stock cancellations, Shares		(5,199)
Net Loss				(22,197,867)	(22,197,867)
Ending Balance at Dec. 31, 2015	$ 80,258	$ 111,243	$ 147,412,559	$ (150,129,933)	$ (2,525,873)
Ending Balance, Shares at Dec. 31, 2015	8,025,793	11,124,496