ResearchMember
FiniteLivedIntangibleAssetsByMajorClass [Axis]
PatentsMember
DrugMember
PharmaceuticalMember
PatentedTechnologyMember
IntangibleassetsMember
FranklinMember
PartiesToContractualArrangement [Axis]
PhiladelphiaMember
ManufacturinglaboratoryandofficespaceMember
PropertyPlantAndEquipmentByType [Axis]
CorporateofficespaceMember
ManufacturinglaboratoryandofficespacemMember
SeriesCPreferredStock [Member]
StatementClassOfStock [Axis]
SeriesDPreferredStock [Member]
Plan2003Member
PlanName [Axis]
Plan2008Member
NotPursuanttoaPlanMember
Grantedtoplacementagentsinprivateplacement1Member
ClassOfWarrantOrRight [Axis]
Grantedtofinancialinvestmentadvisor1Member
Grantedtofinancialadvisorinconnectionwithanacquisition1Member
Grantedtofinancialinvestmentadvisor2Member
Grantedtoinvestorsinprivateplacement1Member
Grantedtoinvestorsinprivateplacement2Member
Grantedtoinvestorsinprivateplacementofpreferredstock1Member
Grantedtoinvestorsinprivateplacementofpreferredstock2Member
Grantedtoinvestorsinprivateplacementofpreferredstock3Member
Grantedtovendor1Member
Grantedtoinvestorsinprivateplacement3Member
Grantedtovendor2Member
Grantedtoinvestorsinprivateplacement4Member
Grantedtoinvestorsinprivateplacement5Member
Grantedtoinvestorinprivateplacement6Member
Grantedtoinvestorsinprivateplacement7Member
Grantedtoinvestorsinprivateplacement8Member
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Grantedtoplacementagentinprivateplacement3Member
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Grantedtoinvestorsinprivateplacement10Member
Grantedtoinvestorsinprivateplacement11Member
Grantedtoinvestorsinprivateplacement12Member
Grantedtoplacementagentinprivateplacement4Member
Grantedtoplacementagentinprivateplacement5Member
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Grantedtoinvestorsinprivateplacement14Member
Grantedtoplacementagentinprivateplacement6Member
Grantedtoplacementagentinprivateplacement7Member
Grantedtoinvestorsinprivateplacement15Member
Grantedtoinvestorsinprivateplacement16Member
Grantedtoplacementagentinprivateplacement8Member
Grantedtoplacementagentinprivateplacement9Member
Grantedtoinvestorsinprivateplacement17Member
Grantedtoinvestorsinprivateplacement18Member
Grantedtoinvestorsinprivateplacement19Member
TotaloutstandingwarrantsaccountedforasequityMember
WeightedaverageexercisepriceMember
WeightedaveragetimetoexpirationinyearsMember
Platinum-Montaur Life Sciences LLC [Member]
Related Party Transactions By Related Party [Axis]
Non-revolving draw credit facility [Member]
Credit Facility [Axis]
Document And Entity Information
Entity Registrant Name
Entity Central Index Key
Document Type
Document Period End Date
Amendment Flag
Current Fiscal Year End Date
Is Entity a Well-known Seasoned Issuer?
Is Entity a Voluntary Filer?
Is Entity's Reporting Status Current?
Entity Filer Category
Entity Public Float
Entity Common Stock, Shares Outstanding
Document Fiscal Period Focus
Document Fiscal Year Focus
Statement of Financial Position [Abstract]
ASSETS
Current Assets:
Cash and cash equivalents
Cash restricted pursuant to letters of credit
Accounts receivable
Stock subscriptions receivable
Prepaid expenses and other current assets
Total current assets
Property and Equipment, at cost:
Computer equipment
Office and laboratory equipment (including assets under capitalized leases)
Furniture and fixtures
Manufacturing equipment
Leasehold improvements
Property and equipment, at cost
Less-Accumulated depreciation and amortization
Net property and equipment (including assets under capitalized leases)
Other Assets:
Intangible assets, net of accumulated amortization
Deposits and other assets
Total other assets
Total assets
LIABILITIES AND STOCKHOLDERS' EQUITY
Current Liabilities:
Accounts payable
Deferred revenue
Current portion of notes payable and capital lease obligation, net of discounts
Derivative warrant liability
Accrued expenses and other liabilities
Total current liabilities
Notes Payable and capital lease obligation, net of current portion and discounts
Deferred revenue, net of current portion
Total liabilities
Commitments
Stockholders' Equity:
Series C, $0.01 par value, authorized 10,000 shares, issued and outstanding 9,974.185 shares at June 30, 2012 and December 31, 2011
Series D, $0.01 par value, authorized 3,600,000 shares, issued and outstanding 3,006,000 shares at June 30, 2012 and December 31, 2011 (preference in liquidation of $3,006,000 at June 30, 2012)
Common Stock, $0.01 par value, authorized 150,000,000 shares, issued and outstanding 39,615,344 and 38,543,944 shares at June 30, 2012 and December 31, 2011, respectively
Additional paid-in capital
Common stock subscribed for but not paid for or issued, 0 and 33,333 shares at June 30, 2012 and December 31, 2011, respectively
Accumulated deficit
Total stockholders' equity
Total liabilities and stockholders' equity
Convertible Preferred Stock: Series C, par value
Convertible Preferred Stock:Series C, authorized
Convertible Preferred Stock:Series C, outstanding
Convertible Preferred Stock:Series C, Share Issued
Convertible Preferred Stock:Series D, par value
Convertible Preferred Stock:Series D, authorized
Convertible Preferred Stock:Series D, outstanding
Convertible Preferred Stock:Series D, Share Issued
Convertible Preferred Stock:Series D,preference in liquidation
Common stock, par value
Common stock, authorized
Common stock, outstanding
Common stock, Share Issued
Income Statement [Abstract]
Licensing revenue
Other revenue
Total revenues
Operating Expenses:
Research and development
Selling, general and administrative
Total operating expenses
Loss from operations
Other Income (Expense):
Interest income
Interest expense
Loss on extinguishment of debt/payables
Gain (loss) on disposals of assets
Derivative warrant liability gain (loss)
Other income (expense), net
Net loss
Deemed dividend on beneficial conversion feature of Series D Convertible Preferred Stock
Accretion of dividends on Convertible Perpetual Redeemable Preferred Stock
Net loss applicable to common shareholders
Net loss per common share, basic and diluted
Basic and diluted weighted average common shares outstanding
Statement of Cash Flows [Abstract]
Cash Flows From Operating Activities:
Net loss
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization
Share-based compensation, net
Fair value of common stock and warrants issued for services
Derivative warrant liability (gain) loss
Non-cash (gain) loss on extinguishment of debt
Non-cash interest expense
Non-cash loss on disposal of assets
Changes in assets and liabilities:
Accounts receivable
Stock subscriptions receivable
Prepaid expenses and other current assets
Deposits and other assets
Accounts payable
Deferred revenue
Accrued expenses and other liabilities
Net cash used in operating activities
Cash Flows from Investing Activities:
Purchase of property and equipment
Increase in restricted cash
Net cash provided by (used in) investing activities
Cash Flows From Financing Activities:
Proceeds from the exercise of warrants
Proceeds from issuance of common stock and warrants, net of issuance costs
Principal payments for capital lease obligations
Proceeds from issuance of Series D Convertible Preferred Stock and warrants, net of issuance costs
Proceeds from bridge notes
Repayment of bridge notes
Proceeds from exercise of stock options
Net cash provided by financing activities
Net increase (decrease) in cash and cash equivalents
Cash and cash equivalents, beginning of period
Cash and cash equivalents, end of period
Supplemental Disclosure of Cash Flow Information and Non Cash Financing Transactions:
Cash paid for interest
Accretion of dividend on Series B Perpetual Redeemable Preferred Stock
Deemed dividend on beneficial conversion of Series D Convertible Preferred Stock
Issuance of common stock in settlement of short term note
Conversion of notes payable and accrued interest into Series D Convertible Preferred Stock
Reclassification of derivative warrant liability to additional paid-in capital
Fair value of warrants issued to investor relations services
Fair value of common stock issued for short-term note extension
Fair value of warrants issued to financial advisors as financing costs
Fair value of common stock issued in connection with settlement agreement
Cancellation of restricted common stock
Notes to Financial Statements
Note 1. ORGANIZATION AND BASIS OF PRESENTATION
Note 2. CASH AND CASH EQUIVALENTS
Note 3. INTANGIBLE ASSETS
Note 4. OPERATING LEASE COMMITMENTS
Note 5. DERIVATIVE WARRANT LIABILITY
Note 6. PREFERRED STOCK
Note 7. COMMON STOCK
Note 8. STOCK OPTIONS AND RESTRICTED STOCK
Note 9. WARRANTS
Note 10. LICENSING AND OTHER REVENUE
Note 11. LITIGATION
Note 12. SUBSEQUENT EVENTS
Organization And Basis Of Presentation Policies
ORGANIZATION AND BASIS OF PRESENTATION
Intangible Assets Tables
INTANGIBLE ASSETS
Operating Lease Commitments Tables
Future minimum lease payments
Derivative Warrant Liability Tables
Derivative warrant liability
Stock Options And Restricted Stock Tables
Share based compensation options
Assumption used for stock option granted
Share based compensation restricted stock
Warrants Tables
Outstanding Warrants
Organization And Basis Of Presentation Details Narrative
Organization And Basis Of Presentation
Cash
Working capital
Accumulated deficit
Cash And Cash Equivalents Details Narrative
Cash And Cash Equivalents
Cash and cash equivalents
Insurance coverage
Statement [Table]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets by Major Class [Axis]
Estimated Life
Cost
Accumulated Amortization
Total
Schedule of Operating Leased Assets [Table]
Operating Leased Assets [Line Items]
Parties to Contractual Arrangement [Axis]
OPERATING LEASE COMMITMENTS
2012
2013
2014
2015
2016
Total
Property, Plant and Equipment by Type [Axis]
Operating Lease Commitments
Company leases
Lease amendment
Facilities lease expense
Office lease expiry date
Derivative Warrant Liability Details
DERIVATIVE WARRANT LIABILITY
Beginning balance
Total unrealized losses included in net loss
Total realized losses included in net loss
Total unrealized gains included in net loss
Total realized gains included in net loss
Reclassification of derivative warrant liability
Ending balance
Derivative Warrant Liability Details Narrative
Outstanding warrants
Derivative financial instruments
Fair value of derivative instruments on recurring basis
Derivative Warrant Liability Gain
Derivative Warrant Liability Loss
Exercised warrants Shares
Reclassification of Derivative Warrant Liability to Additional Paid-in Capital
Schedule of Stock by Class [Table]
Class of Stock [Line Items]
Class of Stock [Axis]
Authorized Preferred Stock
Issued and outstanding
Common Stock Details Narrative
Common stock, shares authorized
Common stock, Shares issued
Common stock, shares outstanding
Shares issued to vendors in exchange of services
Value of shares issued to vendors in exchange of services
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
PlanNameAxis [Axis]
Share-Based Compensation
Shares Available For Issuance
Total reserved for stock options and restricted stock
Net restricted stock issued net of cancellations
Stock options granted
Add back options cancelled before exercise
Options cancelled by plan vote
Remaining shares available for future grants
Outstanding Options and Restricted Stock
Total granted
Cancelled restricted stock
Options cancelled
Options exercised
Net shares outstanding before restricted stock
Net restricted stock issued net of cancellations
Ending Balance
Stock Options And Restricted Stock Details 1
STOCK OPTIONS AND RESTRICTED STOCK
Risk-free interest rate
Risk-free interest rate
Expected dividend yield
Expected term, minimum
Expected term, maximum
Forfeiture rate (excluding fully vested stock options)
Forfeiture rate (excluding fully vested stock options)
Expected volatility
Expected volatility
Stock Options And Restricted Stock Details 2
Stock Options
Shares
Beginning Balance
Granted
Exercised
Forfeited or expired
Ending Balance
Exercisable at March 31, 2012
Weighted-Average Exercise Price
Beginning Balance
Granted
Exercised
Forfeited or expired
Ending Balance
Exercisable at March 31, 2012
Weighted-Average Remaining Contractual Term
Beginning Balance
Ending Balance
Aggregate Intrinsic Value
Beginning Balance
Ending Balance
Stock Options And Restricted Stock Details 3
STOCK OPTIONS AND RESTRICTED STOCK
Shares
Nonvested at January 1, 2012
Granted this period
Grants made in prior periods, now becoming restricted
Vested
Forfeited
Nonvested at March 31, 2012
Weighted- Average Grant-DateFair Value
Nonvested at January 1, 2012
Granted this period
Grants made in prior periods, now becoming restricted
Vested
Forfeited
Nonvested at March 31, 2012
Stock Options And Restricted Stock
Common Stock outstanding
Restricted shares of Common Stock issued and options to purchase an aggregate
Maximum authorized shares
Shares Future grants
Additional paid-in capital and non-cash compensation expense
Weighted-average grant-date fair value of stock options granted
Share-based compensation expense
Total unrecognized compensation expense
Stock Options And Restricted Stock Details Narrative 1
Stock Options And Restricted Stock
Aggregate restricted shares of Common Stock
Fair Value of restricted stock
Outstanding Non Vested restricted stock grants
Total unrecognized compensation expense
Class of Warrant or Right [Table]
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Axis]
Warrants
Number of Shares Exercisable
Exercise Price
Date of Expiration Range Start
Date of Expiration
Total outstanding warrants accounted for as derivative warrant liability
Weighted average exercise price
Weighted average time to expiration in years
Number of Shares Exercisable
Exercise Price
Date of Expiration
Expiration period
Total Warrants Outstanding
Total Weighted average exercise price
Total Weighted average time to expiration in years
Warrants Details 2
Warrants
Shares
Beginning Balance
Granted
Exercised
Forfeited or expired
Ending Balance
Weighted-Average Exercise Price
Beginning Balance
Granted
Exercised
Forfeited or expired
Ending Balance
Warrants Details Narrative
Shares of Common Stock issued upon the exercise of warrants
Licensing And Other Revenue Details Narrative
Received a licensing fee
Non refundable license revenue
Deferred revenue unrecognized
Litigation Details Narrative
Accrued settlement liability
outstanding settlement accrued liability
settlement payment
shares of restricted Common Stock
Schedule of Related Party Transactions, by Related Party [Table]
Related Party Transaction [Line Items]
Related Party Transactions, by Related Party [Axis]
CreditFacilityAxis [Axis]
Non-revolving draw credit facility initial aggregate principal amount
Term of the credit facility
Draw Credit Maximum Amount available, additional increase
Increment in amount maximum
Interest rate on credit draw
Issuance of warrants to purchase common stock
exercise price
Subsequent event description
Assets, Current
OfficeAndLaboratoryEquipment
Property, Plant and Equipment, Gross
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Property, Plant and Equipment, Net
Assets, Noncurrent
Assets
Liabilities, Current
Liabilities
Stockholders' Equity Attributable to Parent
Liabilities and Equity
Revenue, Net
Operating Expenses
Operating Income (Loss)
Interest Expense
GainLossOnDisposalsOfAssets
Nonoperating Income (Expense)
Net Income (Loss) Available to Common Stockholders, Basic
Increase (Decrease) in Accounts Receivable
StockSubscriptionsReceivable
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Other Noncurrent Assets
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Deferred Revenue
Increase (Decrease) in Accrued Liabilities
Net Cash Provided by (Used in) Operating Activities
Payments to Acquire Machinery and Equipment
Increase (Decrease) in Restricted Cash
Net Cash Provided by (Used in) Investing Activities
Repayments of Long-term Capital Lease Obligations
Repayments of Short-term Debt
Net Cash Provided by (Used in) Financing Activities
Schedule of Derivative Liabilities at Fair Value [Table Text Block]
Development Stage Enterprise, Deficit Accumulated During Development Stage
CashAndCashEquivalents1
FiniteLivedIntangibleAssetUsefulLife3
OperatingLeasesFutureMinimumPaymentsNextRollingTwelveMonths
OperatingLeasesFutureMinimumPaymentsDueInRollingYearTwo
OperatingLeasesFutureMinimumPaymentsDueInRollingYearThree
OperatingLeasesFutureMinimumPaymentsDueInRollingYearFour
OperatingLeasesFutureMinimumPaymentsDueInRollingYearFive
Operating Leases, Future Minimum Payments Due
DerivativeWarrants
Warrants and Rights Outstanding
Stock Issued During Period, Shares, Restricted Stock Award, Forfeited
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber1
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeiturerateMaximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm3
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsMadeInPriorPeriodWeightedAverageGrantDateFairValue
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue
DisclosureOfCompensationRelatedCostsSharebasedPayments2Abstract
TotalUnrecognizedCompensationExpense1
ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights1
ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
InvestmentWarrantsExpirationDate
DisclosureOfCompensationRelatedCostsSharebasedPayments1Abstract
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingAbstract
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber1
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted1
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeitures
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceAbstract
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice1
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice1
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice1
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice1
BasicAndDilutedWeightedAverageCommonSharesOutstanding
Custom Element
ComputerEquipment
Conversion of Notes Payable and Accrued Interest into Series D Convetible Preferred Stock
DeemedDividendOnBeneficialConversionFeatureOfSeriesDConvertiblePreferredStock
Deemed Dividend on Beneficial Conversion Feature of Series D Convertible Preferred Stock
DerivativeWarrantLiabilityTextBlock
FairValueOfCommonStockAndWarrantsIssuedForServices
Custom Element
Custom Element
Custom Element
Issuance of Common Stock in Settlement of Short Term Note
NoncashGainLossOnExtinguishmentOfDebt
Period end amount of property, plant and equipment (PPE) related to regulated assets common to business units.
Reclassification of Derivative Liability to Additional Paid In Capital
Custom Element
SeriesCAuthorized
SeriesCOutstanding
Custom Element.
SeriesCShareIssued
Custom Element
SeriesDAuthorized
SeriesDOutstanding
SeriesDParValue
SeriesDShareIssued
WarrantsTextBlock
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Companys Facilities Lease Expense1.
Common Stock Shares Outstanding1.
Warrants Expiration Period.
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number1.