X0303 5 2009-12-31 0 0 1 0001031927 Echo Therapeutics, Inc. ECTE 0001367655 Mitchell Harry 10 FORGE PARKWAY FRANKLIN MA 02038 0 1 0 0 CFO and COO Common Stock 2008-05-30 4 A 0 L 11187 A 892687 D Common stock 2009-02-20 4 A 0 L 175000 0 A 892687 D Common stock 2009-06-15 4 A 0 L 175000 0 A 892687 D Non-qualified stock option 2.39 2009-02-20 4 D 0 L 250000 2.39 D 2017-09-14 Common stock 250000 892687 D Non-qualified stock options 0.21 2008-05-30 4 X 0 L 12500 0.21 A 2007-01-30 2017-01-30 Common stock 12500 892687 D The recipient transacted a Cashless Exercise of 12,500 NQSOs on May 30, 2008. Includes 475,000 shares that may be acquired by Mr. Mitchell within 60 days upon the exercise of stock options and 1,500 shares of common stock which Mr. Mitchell may acquire within 60 days upon exercise of warrants. One third of the options vested on September 14, 2007, options to purchase 83,333 shares vested on September 14, 2008, and the final one third (83,333) would have vested on September 14, 2009. The restricted shares shall vest upon the first to occur of (i) FDA approval of the Companys Symphony tCGM System; or (ii) the sale of all or substantially all of the assets of the Company or all or substantially all of the outstanding capital stock of the Company in exchange for liquid proceeds, which was defined as (a) cash; (b) securities which can be sold immediately on NYSE or NASDAQ; (c) securities which are or will be registered such that they can be sold upon on NYSE or NASDAQ upon termination of a lock-up period not to exceed one hundred eighty (180) days; or (d) or a combination of cash and the foregoing securities. Harry G. Mitchell 2010-04-30