<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001251708</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000103145</issuerCik>
      <issuerName>VEECO INSTRUMENTS INC</issuerName>
      <secFileNumber>000-16244</secFileNumber>
      <issuerAddress>
        <com:street1>TERMINAL DRIVE</com:street1>
        <com:city>PLAINVIEW</com:city>
        <com:stateOrCountry>NY</com:stateOrCountry>
        <com:zipCode>11803</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>516 677-0200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KIERNAN JOHN P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>1 N. Jefferson Ave.</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2500</noOfUnitsSold>
      <aggregateMarketValue>51641.56</aggregateMarketValue>
      <noOfUnitsOutstanding>57935847</noOfUnitsOutstanding>
      <approxSaleDate>03/10/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/22/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2500</amountOfSecuritiesAcquired>
      <paymentDate>03/22/2023</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Kiernan</name>
        <address>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common shares of VECO</securitiesClassTitle>
      <saleDate>02/10/2025</saleDate>
      <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
      <grossProceeds>61216.30</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Kiernan</name>
        <address>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common shares of VECO</securitiesClassTitle>
      <saleDate>12/10/2024</saleDate>
      <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
      <grossProceeds>71941.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>John Kiernan</name>
        <address>
          <com:street1>1 Terminal Drive</com:street1>
          <com:city>Plainview</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>11803</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common shares of VECO</securitiesClassTitle>
      <saleDate>01/10/2025</saleDate>
      <amountOfSecuritiesSold>2500</amountOfSecuritiesSold>
      <grossProceeds>69016.08</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares were sold by the John &amp; Elaine Kiernan Trust. John P. Keirnan is a trustee of the trust and is also an officer of VECO.</remarks>
    <noticeSignature>
      <noticeDate>03/10/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/29/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>John P. Kiernan</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
