<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-12-08</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000706539</issuerCik>
        <issuerName>CHIRON CORP</issuerName>
        <issuerTradingSymbol>CHIRON COR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001031007</rptOwnerCik>
            <rptOwnerName>NOVARTIS CORP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>608 FIFTH AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10020</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001114448</rptOwnerCik>
            <rptOwnerName>NOVARTIS AG</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>LICHTSTRASSE 35</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BASEL SWITZERLAND</rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode>CH 4002</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2005-12-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6896552</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>43.50</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>80746860</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On October 30, 2005, Chiron Corporation (the &quot;Company&quot;) gave Novartis AG and Novartis Corporation, an indirect wholly-owned
 subsidiary of Novartis AG, notice of the exercise of its right, pursuant to the Subscription Agreement, dated as of November
 20, 1994, among the Company, Novartis AG and certain of its affiliates, to require Novartis Biotech Partnership, Inc., an
 indirect wholly-owned subsidiary of Novartis AG and an indirect subsidiary of Novartis Corporation (&quot;Novartis Biotech&quot;), to
 purchase an aggregate of $300,000,000 worth of shares of Common Stock at $43.50 per share directly from the Company.
 Pursuant to that notice, on December 8, 2005, Novartis Biotech completed the purchase of 6,896,552 shares of Common Stock
 from Chiron for $43.50 per share, resulting in an aggregate purchase price of $300,000,012.</footnote>
        <footnote id="F2">Following the transaction, Novartis Biotech is the record holder of 80,739,404 shares of Common Stock.  Novartis Corporation
 is the record holder of 7,456 shares of Common Stock and is the indirect beneficial owner of the shares of Common Stock
 owned of record by Novartis Biotech.  Novartis Pharma AG, an indirect wholly-owned subsidiary of Novartis AG, is the record
 holder of 5,469,770 shares of Common Stock.  Novartis AG is the indirect beneficial owner of all shares owned through
 Novartis Biotech, Novartis Corporation and Novartis Pharma AG, resulting in indirect beneficial ownership of 86,216,630
 shares of Common Stock.</footnote>
        <footnote id="F3">Pursuant to the Market Price Option Agreement, dated as of November 20, 1994, among the Company, Novartis AG, Novartis
 Corporation and Novartis Biotech, Novartis Biotech or its designee, which must be Novartis AG or a subsidiary thereof, has
 the right to purchase from the Company under certain circumstances such number of shares of Common Stock as are necessary
 for the Reporting Persons to maintain collectively up to a 55% ownership interest in the Company, which as of October 31,
 2005, constituted the right to purchase an additional 47,318,084 shares, based on 195,472,305 shares of Common Stock
 outstanding at October 31, 2005, as reported in the Company's Preliminary Proxy Statement filed with the Securities and
 Exchange Commission on November 25, 2005.</footnote>
        <footnote id="F4">The purchase price of any shares purchased pursuant to the Market Price Option Agreement will be the fair market value of the
 shares, determined as of the business day three business days prior to the closing of the purchase, where fair market value
 is generally the average of the closing sale prices on the Nasdaq National Market of shares of Common Stock during the
 10-day period immediately preceding the date of determination of fair market value.  Novartis AG and Novartis Corporation
 are indirect beneficial owners of any shares purchased by Novartis Biotech pursuant to the Market Price Option Agreement.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Novartis Corporation, Jeff Benjamin, Vice President and General Counsel</signatureName>
        <signatureDate>2005-12-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
