X0303 4 2008-12-08 1 0001408808 PEPLIN INC PLIN 0001399666 ORBIS HOLDINGS TRUST LPG BUILDING 34 BERMUDIANA ROAD HAMILTON D0 HM 11 BERMUDA 0 0 0 1 Former 10% Owner 0001399670 ORBIS TRUST BOULEVARD GEORGES FAVON 29 GENEVA V8 CH-1204 SWITZERLAND 0 0 0 1 Former 10% Owner 0001399536 PICTET TRUSTEE CO S A BOULEVARD GEORGES FAVON 29 GENEVA V8 CH-1204 SWITZERLAND 0 0 0 1 Former 10% Owner 0001399533 PICTET OVERSEAS TRUST CORP LTD BAYSIDE EXECUTIVE PARK WEST BAY STREET NASSAU C5 0000000000 BAHAMAS 0 0 0 1 Former 10% Owner 0001399486 ORBIS WORLD LTD LPG BUILDING 34 BERMUDIANA ROAD HAMILTON D0 HM 11 BERMUDA 0 0 0 1 Former 10% Owner 0001086504 ORBIS HOLDINGS LTD 34 BERMUDIANA RD HAMILTON HM 11 BERMUDA 00000 0 0 0 1 Former 10% Owner 0000940594 ORBIS INVESTMENT MANAGEMENT LTD ORBIS LPG BLDG 34 BERMUDIANA ROAD HAMILTON HM11 BERMUD D0 BERMUDA 0 0 0 1 Former 10% Owner 0001025890 ORBIS ASSET MANAGEMENT LTD 34 BERMUDIANA RD HAMILTON HM11 D0 00000 BERMUDA 0 0 0 1 Former 10% Owner Common Stock 0 I See footnotes The reporting persons are submitting this Form 4 relying on Rules 16a-1(a)(1)(x) and (xi), which became effective 8 December 2008. Accordingly, filing of this Form 4 is based on such reporting persons no longer being considered as "beneficial owners" of Peplin, Inc. common stock. By six investment funds (Orbis MIS-Orbis Global Equity Fund, Orbis Global Equity Fund Limited, Orbis Optimal SA Fund Limited, Orbis Sicav - Global Equity Fund, Orbis Sicav - Asia Ex Japan Fund, Orbis Optimal Global Fund LP) in which Pictet Trustee Company SA and Pictet Overseas Trust Corporation Limited, through the other reporting persons, have an ownership interest which varies from time to time, based on the outstanding equity interests of the funds. /s/James Dorr 2009-02-27