X0306 4 2014-04-30 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001486430 Smith James Edward Jr. 700 CAMP STREET NEW ORLEANS LA 70130 0 0 1 0 Common Stock 2014-04-30 4 S 0 15000 4.7193 D 4397704 D Common Stock 2014-05-01 4 S 0 15000 4.6324 D 4382704 D Common Stock 3200 I By Daughter The sales reported in the Form 4 were effected pursuant to Rule 144. The price reported in Table I is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.59 to $4.81, inclusive. The reporting person will provide Pernix Therapeutics Holdings, Inc, any security holder of Pernix Therapeutics Holdings, Inc, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Table I is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.53 to $4.79, inclusive. The reporting person will provide Pernix Therapeutics Holdings, Inc, any security holder of Pernix Therapeutics Holdings, Inc, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Smith James Edward Jr 2014-05-01