X0306 4 2019-01-05 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001607857 Pina Kenneth C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 0 1 0 0 SVP, GC,Compliance Off & Sec Common Stock 2019-01-05 4 F 0 417 0.449 D 14726 D Represents restricted stock units ("RSUs") of Pernix Therapeutics Holdings, Inc. withheld to satisfy tax withholding obligations in connection with the vesting of RSUs, exempt under Rule 16b-3. Consists of (i) 2,726 shares of common stock owned directly, (ii) the unvested amount of previously-awarded RSUs that vest in four equal annual installments of 1,250 shares with the third installment vesting on January 5, 2020, (iii) the unvested amount of previously-awarded RSUs that vest in four equal annual installments of 1,500 shares, with the second installment vesting on August 8, 2019 and (iv) the unvested amount of previously-awarded RSUs that vest in four equal installments of 1,250 shares, with the first installment vesting on March 15, 2019. /s/ Kenneth R. Pina 2019-01-08