X0306 4 2018-07-26 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001337409 Sedor John A C/O PERNIX THERAPEUTICS, INC. 10 N. PARK PLACE MORRISTOWN NJ 07960 1 1 0 0 Chairman of Board and CEO Common Stock 2018-07-26 4 F 0 11982 2.53 D 133825 D Represents restricted stock units ("RSU") of Pernix Therapeutics Holdings, Inc. withheld to satisfy tax withholding obligations in connection with the vesting of RSUs, exempt under Rule 16b-3. Consists of (i) 62,125 shares of common stock, (ii) the unvested amount of previously-awarded RSUs with the remaining 43,700 shares vesting on July 26, 2019, (iii) the unvested amount of previously awarded RSUs that vest in four equal annual installments of 2,500, with the first installment vesting on August 8, 2018 and (iv) the unvested amount of previously awarded RSUs that vest in four equal annual installments of 4,500, with the first installment vesting on March 15, 2019. Kenneth R. Pina, Attorney-in-Fact for John A. Sedor 2018-07-27