X0306 4 2018-03-15 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001730835 Smith Angus W. C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 0 1 0 0 SVP, Chief Bus Off & PFO Common Stock 2018-03-15 4 A 0 5000 0 A 8300 D Stock Option (right to buy) 2.46 2018-03-15 4 A 0 15000 0 A 2028-03-14 Common Stock 15000 15000 D Represents a grant of restricted share units ("RSUs") that vest in four equal annual installments of 1,250 shares over a four-year period, with the first installment vesting on March 15, 2019, which is the one-year anniversary of the grant date. Consists of (i) the unvested amount of previously awarded RSUs that vest in four equal installments of 825 shares, with the first installment vesting on August 8, 2018, which is the one-year anniversary of the grant date and (ii) and the unvested amount of RSUs that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 3,750 shares over a four-year period, with the first installment vesting at the close of business on March 15, 2019, which is the one-year anniversary of the grant date. /s/ Kenneth R. Pina, Attorney-in-Fact for Angus W. Smith 2018-03-16