X0306 4 2018-03-15 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001724623 Whaley Glenn C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 0 1 0 0 Interim VP Fin, PAO & Controll Common Stock 2018-03-15 4 A 0 2600 0 A 3700 D Stock Option (right to buy) 2.46 2018-03-15 4 A 0 7800 0 A 2028-03-14 Common Stock 7800 7800 D Represents a grant of restricted share units ("RSUs") that vest in four equal annual installments of 650 shares over a four-year period, with the first installment vesting on March 15, 2019, which is the one-year anniversary of the grant date. Consists of (i) the unvested amount of previously awarded RSUs that vest in four equal installments of 275 shares, with the first installment vesting on August 8, 2018, which is the one-year anniversary of the grant date, and (ii) and the unvested amount of the RSUs that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 1,950 shares over a four-year period, with the first installment vesting at the close of business on March 15, 2019, which is the one-year anniversary of the grant date. /s/ Kenneth R. Pina, Attorney-in-Fact for Glenn Whaley 2018-03-16