X0306 4 2018-03-15 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001337409 Sedor John A C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 N. PARK PLACE MORRISTOWN NJ 07960 1 1 0 0 Chairman of the Board & CEO Common Stock 2018-03-15 4 A 0 18000 0 A 145807 D Stock Option (right to buy) 2.46 2018-03-15 4 A 0 64000 0 A 2028-03-14 Common Stock 64000 64000 D Represents a grant of restricted share units ("RSUs") that vest in four equal annual installments of 4,500 over a four-year period, with the first installment vesting on March 15, 2019, which is the one-year anniversary of the grant date. Consists of (i) 30,407 shares of common stock, (ii) the unvested amount of previously-awarded RSUs that vests in two equal installments of 43,700 shares, with the next installment vesting on July 26, 2018 and the final installment vesting on July 26, 2019, (iii) the unvested amount of previously awarded RSUs that vest in four equal annual installments of 2,500, with the first installment vesting on August 8, 2018 and (iv) the unvested amount of the RSUs that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 16,000 shares over a four-year period, with the first installment vesting at the close of business on March 15, 2019, which is the one-year anniversary of the grant date. /s/ John A. Sedor 2018-03-16