X0306 4 2017-08-08 0 0001024126 PERNIX THERAPEUTICS HOLDINGS, INC. PTX 0001607857 Pina Kenneth C/O PERNIX THERAPEUTICS HOLDINGS, INC. 10 NORTH PARK PLACE, SUITE 201 MORRISTOWN NJ 07960 0 1 0 0 SVP, Gen Counsel & Comp Off Common Stock 2017-08-08 4 A 0 6000 0 A 11000 D Stock Option (right to buy) 2.78 2017-08-08 4 A 0 18000 0 A 2027-08-08 Common Stock 18000 18000 D Represents a grant of restricted share units that vest in four equal annual installments of 1,500 shares over a four-year period, with the first installment vesting on August 8, 2018, which is the one-year anniversary of the grant date. Consists of (x) the unvested amount of previously-awarded restricted share units that vest in four equal annual installments of 1,250 shares, with the first installment vesting on January 4, 2018, which is the one year anniversary of the grant date, and (y) the unvested amount of the restricted share units that vest as described in footnote 1 above. The stock option vests in four equal annual installments of 4,500 shares over a four-year period, with the first installment vesting at the close of business on August 8, 2018, which is the one-year anniversary of the grant date. /s/ Kenneth R. Pina 2017-08-09